Exposure to GSM 900-MHz mobile radiation impaired inhibitory avoidance memory consolidation in rat: Involvements of opioidergic and nitrergic systems

2018 · Harm · Low evidence

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HarmLow evidencePaper 2050

Study snapshot

Publicationmanual · 2018

Study typeanimal

Reported directionHarm

Evidence ratingLow

Abstract

Exposure to GSM 900-MHz mobile radiation impaired inhibitory avoidance memory consolidation in rat: Involvements of opioidergic and nitrergic systems Ahmadi S, Alavi SS, Jadidi M, Ardjmand A. Exposure to GSM 900-MHz mobile radiation impaired inhibitory avoidance memory consolidation in rat: Involvements of opioidergic and nitrergic systems. Brain Research. 1701:36-45. Dec 2018. doi.org. Highlights • Four weeks of exposure to GSM radiation impaired IA memory performance.\ • Post-training i.c.v. injections of naloxone recovered the impairment of IA memory. • Pre-test i.c.v. injections of L-NAME impaired the positive effect of naloxone • Pre-test co-administration of L-arginine and L-NAME recovered the impairment. • Opioid and NO systems are involved in the effects of GSM exposure on IA memory. Abstract The use of mobile phones is increasing, and the main health concern is the possible deleterious effects of radiation on brain functioning. The present study aimed to examine the effects of exposure to a global system for mobile communication (GSM) with mobile phones on inhibitory avoidance (IA) memory performance as well as the involvement of endogenous opioids and nitric oxide (NO) in this task. Male Wistar rats, 10-12 weeks old, were used. The results showed that four weeks of mobile phone exposure impaired IA memory performance in rats. The results also revealed that post-training, but not pre-training, as well as pre-test intracerebroventricular (i.c.v.) injections of naloxone (0.4, 4 and 40 ng/rat), dose-dependently recovered the impairment of IA memory performance induced by GSM radiation. Additionally, the impairment of IA memory performance was completely recovered in the exposed animals with post-training treatment of naloxone (40 ng/rat) plus pre-test i.c.v. injections of L-arginine (100 and 200 nmol/rat). However, pre-test i.c.v. injections of L-NAME (10 and 20 nmol/rat), impaired IA memory performance in the animals receiving post-training naloxone (40 ng/rat). In the animals receiving post-training naloxone treatment, the impairment of IA memory performance due to pre- test i.c.v. injections of L-NAME was recovered by the pre-test co-administration of L-arginine. It was concluded that the recovery from impairment of IA memory in GSM-exposed animals with post-training naloxone treatment was the result of blockade of the opioidergic system in early memory consolidation as well as activation of the nitrergic system in the retrieval phase of memory. sciencedirect.com

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal

Effect directionharm

PopulationMale Wistar rats (10–12 weeks old)

Sample sizeNot supplied

ExposureRF · 900 MHz · Four weeks

Evidence strengthLowConfidence: 78% · Peer reviewed: yes

Main findings

Four weeks of GSM 900-MHz mobile phone exposure impaired inhibitory avoidance memory performance in rats. Post-training (but not pre-training) and pre-test i.c.v. naloxone dose-dependently recovered the exposure-associated impairment; L-NAME interfered with naloxone’s positive effect and L-arginine reversed L-NAME-related impairment, suggesting involvement of opioidergic and nitrergic systems.

Outcomes measured

Inhibitory avoidance (IA) memory performance
Memory consolidation
Opioidergic system involvement (naloxone effects)
Nitrergic system involvement (L-NAME, L-arginine effects)

Limitations

Sample size not reported in provided abstract/metadata
Specific exposure metrics (e.g., SAR, power density) not reported in provided abstract/metadata
Animal study; generalizability to humans not addressed in provided abstract/metadata

View raw extracted JSON

{
  "study_type": "animal",
  "exposure": {
    "band": "RF",
    "source": "mobile phone",
    "frequency_mhz": 900,
    "sar_wkg": null,
    "duration": "Four weeks"
  },
  "population": "Male Wistar rats (10–12 weeks old)",
  "sample_size": null,
  "outcomes": [
    "Inhibitory avoidance (IA) memory performance",
    "Memory consolidation",
    "Opioidergic system involvement (naloxone effects)",
    "Nitrergic system involvement (L-NAME, L-arginine effects)"
  ],
  "main_findings": "Four weeks of GSM 900-MHz mobile phone exposure impaired inhibitory avoidance memory performance in rats. Post-training (but not pre-training) and pre-test i.c.v. naloxone dose-dependently recovered the exposure-associated impairment; L-NAME interfered with naloxone’s positive effect and L-arginine reversed L-NAME-related impairment, suggesting involvement of opioidergic and nitrergic systems.",
  "effect_direction": "harm",
  "limitations": [
    "Sample size not reported in provided abstract/metadata",
    "Specific exposure metrics (e.g., SAR, power density) not reported in provided abstract/metadata",
    "Animal study; generalizability to humans not addressed in provided abstract/metadata"
  ],
  "evidence_strength": "low",
  "confidence": 0.78,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "GSM",
    "900 MHz",
    "mobile phone radiation",
    "RF exposure",
    "inhibitory avoidance",
    "memory consolidation",
    "naloxone",
    "opioidergic system",
    "nitric oxide",
    "nitrergic system",
    "L-NAME",
    "L-arginine",
    "rat"
  ],
  "suggested_hubs": [
    {
      "slug": "mobile-phones-rf",
      "weight": 0.9,
      "reason": "Study examines GSM 900-MHz mobile phone radiation exposure and neurobehavioral outcomes in rats."
    }
  ]
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1016/j.brainres.2018.07.016
PubMed: Not supplied

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