Two Forms of Electrical Transmission Between Neurons

2018 · Unclear · Insufficient evidence

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UnclearInsufficient evidencePaper 1949

Study snapshot

Publicationmanual · 2018

Study typereview

Reported directionUnclear

Evidence ratingInsufficient

Abstract

Two Forms of Electrical Transmission Between Neurons Faber DS, Pereda AE. Two Forms of Electrical Transmission Between Neurons. Front Mol Neurosci. 2018 Nov 21;11:427. doi: 10.3389/fnmol.2018.00427. Abstract Electrical signaling is a cardinal feature of the nervous system and endows it with the capability of quickly reacting to changes in the environment. Although synaptic communication between nerve cells is perceived to be mainly chemically mediated, electrical synaptic interactions also occur. Two different strategies are responsible for electrical communication between neurons. One is the consequence of low resistance intercellular pathways, called "gap junctions", for the spread of electrical currents between the interior of two cells. The second occurs in the absence of cell-to-cell contacts and is a consequence of the extracellular electrical fields generated by the electrical activity of neurons. Here, we place present notions about electrical transmission in a historical perspective and contrast the contributions of the two different forms of electrical communication to brain function. Open access paper: frontiersin.org

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typereview

Effect directionunclear

PopulationNot supplied

Sample sizeNot supplied

ExposureNot supplied

Evidence strengthInsufficientConfidence: 74% · Peer reviewed: yes

Main findings

The article describes two strategies for electrical communication between neurons: (1) direct current spread through low-resistance intercellular pathways (gap junctions) and (2) transmission via extracellular electrical fields generated by neuronal activity in the absence of cell-to-cell contacts. It contrasts the contributions of these two forms of electrical communication to brain function in a historical perspective.

Outcomes measured

Electrical synaptic interactions
Gap junction-mediated electrical transmission
Extracellular field (ephaptic) transmission
Contributions of electrical communication to brain function

View raw extracted JSON

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  "outcomes": [
    "Electrical synaptic interactions",
    "Gap junction-mediated electrical transmission",
    "Extracellular field (ephaptic) transmission",
    "Contributions of electrical communication to brain function"
  ],
  "main_findings": "The article describes two strategies for electrical communication between neurons: (1) direct current spread through low-resistance intercellular pathways (gap junctions) and (2) transmission via extracellular electrical fields generated by neuronal activity in the absence of cell-to-cell contacts. It contrasts the contributions of these two forms of electrical communication to brain function in a historical perspective.",
  "effect_direction": "unclear",
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  "peer_reviewed_likely": "yes",
  "keywords": [
    "electrical signaling",
    "neurons",
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    "gap junctions",
    "extracellular electrical fields",
    "ephaptic transmission",
    "brain function",
    "historical perspective"
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}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.3389/fnmol.2018.00427
PubMed: Not supplied

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