RF Safe

Effect of static magnetic field on DNA synthesis: The interplay between DNA chirality and magnetic field left- right asymmetry.

2020 · Mixed · Insufficient evidence

← Research stream
MixedInsufficient evidencePaper 1563

The authors report a chirality-driven effect of static magnetic fields on DNA synthesis, with different DNA synthesis rates in upward versus downward static magnetic fields, leading to unequal cell proliferation depending on field direction.

Study snapshot

Publicationmanual · 2020
Study typeother
Reported directionMixed
Evidence ratingInsufficient

Abstract

Effect of static magnetic field on DNA synthesis: The interplay between DNA chirality and magnetic field left- right asymmetry. Yang X, Li Z, Polyakova T, Dejneka A, Zablotskii V, Zhang X. Effect of static magnetic field on DNA synthesis: The interplay between DNA chirality and magnetic field left-right asymmetry. FASEB Bioadv. 2020 Mar 7;2(4):254- 263. doi: 10.1096/fba.2019-00045. Abstract Interactions between magnetic fields (MFs) and living cells may stimulate a large variety of cellular responses to a MF, while the underlying intracellular mechanisms still remain a great puzzle. On a fundamental level, the MF - cell interaction is affected by the two broken symmetries: (a) left-right (LR) asymmetry of the MF and (b) chirality of DNA molecules carrying electric charges and subjected to the Lorentz force when moving in a MF. Here we report on the chirality-driven effect of static magnetic fields (SMFs) on DNA synthesis. This newly discovered effect reveals how the interplay between two fundamental features of symmetry in living and inanimate nature-DNA chirality and the inherent features of MFs to distinguish the left and right-manifests itself in different DNA synthesis rates in the upward and downward SMFs, consequently resulting in unequal cell proliferation for the two directions of the field. The interplay between DNA chirality and MF LR asymmetry will provide fundamental knowledge for many MF-induced biological phenotypes. Open access paper: ncbi.nlm.nih.gov

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeother
Effect directionmixed
Populationliving cells
Sample sizeNot supplied
Exposurestatic
Evidence strengthInsufficientConfidence: 62% · Peer reviewed: yes

Main findings

The authors report a chirality-driven effect of static magnetic fields on DNA synthesis, with different DNA synthesis rates in upward versus downward static magnetic fields, leading to unequal cell proliferation depending on field direction.

Outcomes measured

  • DNA synthesis rate
  • cell proliferation

Limitations

  • No sample size reported in provided abstract/metadata
  • No exposure intensity/field strength reported in provided abstract/metadata
  • Study design details (e.g., controls, randomization) not described in provided abstract/metadata
View raw extracted JSON
{
  "study_type": "other",
  "exposure": {
    "band": "static",
    "source": "static magnetic field",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": null
  },
  "population": "living cells",
  "sample_size": null,
  "outcomes": [
    "DNA synthesis rate",
    "cell proliferation"
  ],
  "main_findings": "The authors report a chirality-driven effect of static magnetic fields on DNA synthesis, with different DNA synthesis rates in upward versus downward static magnetic fields, leading to unequal cell proliferation depending on field direction.",
  "effect_direction": "mixed",
  "limitations": [
    "No sample size reported in provided abstract/metadata",
    "No exposure intensity/field strength reported in provided abstract/metadata",
    "Study design details (e.g., controls, randomization) not described in provided abstract/metadata"
  ],
  "evidence_strength": "insufficient",
  "confidence": 0.62,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "static magnetic field",
    "DNA chirality",
    "left-right asymmetry",
    "Lorentz force",
    "DNA synthesis",
    "cell proliferation"
  ],
  "suggested_hubs": []
}
AI can be wrong. Always verify against the paper.

AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1096/fba.2019-00045
PubMed: Not supplied

Read the original paper →

Related papers

← Back to the Research Library