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Alteration of intrapancreatic serotonin, homocysteine, TNF-α, and NGF levels as predisposing factors for

Toxicology and industrial health · 2021 · Harm · Low evidence

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HarmLow evidencePaper 1033

Compared with controls, exposed rats had significantly decreased pancreatic serotonin and NGF levels and significantly increased pancreatic Hcy and TNF-α levels (p < 0.05). Long-time exposure (4 h/day) showed lower serotonin and NGF than short-time exposure (…

Study snapshot

PublicationToxicology and industrial health · 2021
Study typeanimal
Reported directionHarm
Evidence ratingLow

Abstract

Alteration of intrapancreatic serotonin, homocysteine, TNF-α, and NGF levels as predisposing factors for diabetes following exposure to 900-MHz waves Gholamali Jelodar, Mansour Azimzadeh, Fatemeh Radmard, Narges Darvishhoo. Alteration of intrapancreatic serotonin, homocysteine, TNF-α, and NGF levels as predisposing factors for diabetes following exposure to 900- MHz waves. Toxicol Ind Health. 2021 Aug;37(8):496-503. doi: 10.1177/07482337211022634. Abstract Exposure to mobile phone radiation causes deleterious health effects on biological systems. The objects of this study were to investigate the effect of 900-MHz radiofrequency waves (RFW) emitted from base transceiver station antenna on intrapancreatic homocysteine (Hcy), tumor necrosis factor-α (TNF-α), and nerve growth factor (NGF) as predisposing factors involved in pancreatic beta cell damage. Thirty male rats (Sprague-Dawley, 200 ± 10 g) were randomly divided into the control (without any exposure) and exposed groups: short time (2 h/day), long time (4 h/day), and exposed to 900-MHz RFW for 30 consecutive days. On the last days of the experiment, animals were killed and pancreas tissue was dissected out for evaluation of serotonin, Hcy, TNF-α, and NGF. There was a significant decrease in the serotonin and NGF levels in the pancreatic tissue of exposed groups compared to the control group (p < 0.05). Also, the levels of serotonin and NGF in the long-time exposure were significantly lower than the short-time exposure (p < 0.05). However, levels of Hcy and TNF-α were significantly increased in the pancreas of exposed groups compared to the control groups (p < 0.05). Exposure to 900-MHz RFW decreased pancreatic NGF and serotonin levels and increased the proinflammatory markers (Hcy and TNF-α), which can be a predisposing factor for type 2 diabetes. pubmed.ncbi.nlm.nih.gov

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal
Effect directionharm
PopulationMale Sprague-Dawley rats (200 ± 10 g)
Sample size30
ExposureRF · 900 MHz · 2 h/day or 4 h/day for 30 consecutive days
Evidence strengthLowConfidence: 78% · Peer reviewed: yes

Main findings

Compared with controls, exposed rats had significantly decreased pancreatic serotonin and NGF levels and significantly increased pancreatic Hcy and TNF-α levels (p < 0.05). Long-time exposure (4 h/day) showed lower serotonin and NGF than short-time exposure (2 h/day) (p < 0.05).

Outcomes measured

  • Intrapancreatic serotonin levels
  • Intrapancreatic homocysteine (Hcy) levels
  • Intrapancreatic tumor necrosis factor-α (TNF-α) levels
  • Intrapancreatic nerve growth factor (NGF) levels

Limitations

  • No SAR or exposure intensity metrics reported in abstract
  • Only male rats studied
  • Outcomes limited to biochemical markers; diabetes incidence or glucose/insulin measures not reported in abstract
  • Exposure described as from a base transceiver station antenna; dosimetry details not provided in abstract
View raw extracted JSON
{
  "study_type": "animal",
  "exposure": {
    "band": "RF",
    "source": "base transceiver station antenna",
    "frequency_mhz": 900,
    "sar_wkg": null,
    "duration": "2 h/day or 4 h/day for 30 consecutive days"
  },
  "population": "Male Sprague-Dawley rats (200 ± 10 g)",
  "sample_size": 30,
  "outcomes": [
    "Intrapancreatic serotonin levels",
    "Intrapancreatic homocysteine (Hcy) levels",
    "Intrapancreatic tumor necrosis factor-α (TNF-α) levels",
    "Intrapancreatic nerve growth factor (NGF) levels"
  ],
  "main_findings": "Compared with controls, exposed rats had significantly decreased pancreatic serotonin and NGF levels and significantly increased pancreatic Hcy and TNF-α levels (p < 0.05). Long-time exposure (4 h/day) showed lower serotonin and NGF than short-time exposure (2 h/day) (p < 0.05).",
  "effect_direction": "harm",
  "limitations": [
    "No SAR or exposure intensity metrics reported in abstract",
    "Only male rats studied",
    "Outcomes limited to biochemical markers; diabetes incidence or glucose/insulin measures not reported in abstract",
    "Exposure described as from a base transceiver station antenna; dosimetry details not provided in abstract"
  ],
  "evidence_strength": "low",
  "confidence": 0.78,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "900 MHz",
    "radiofrequency waves",
    "base transceiver station",
    "rats",
    "pancreas",
    "serotonin",
    "homocysteine",
    "TNF-α",
    "NGF",
    "inflammation",
    "type 2 diabetes"
  ],
  "suggested_hubs": [
    {
      "slug": "rf-health-effects",
      "weight": 0.9,
      "reason": "Animal study assessing biological effects of 900-MHz RF exposure."
    },
    {
      "slug": "mobile-networks-base-stations",
      "weight": 0.75,
      "reason": "Exposure source described as base transceiver station antenna."
    }
  ]
}
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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1177/07482337211022634
PubMed: 34151670

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