Influence of hypomagnetic field on the heartbeat in zebrafish embryos

2022 · Harm · Low evidence

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HarmLow evidencePaper 664

Study snapshot

Publicationmanual · 2022

Study typeanimal

Reported directionHarm

Evidence ratingLow

Abstract

Influence of hypomagnetic field on the heartbeat in zebrafish embryos Krylov V, Machikhin A, Sizov D, et al. Influence of hypomagnetic field on the heartbeat in zebrafish embryos. Front Physiol. 2022;13:1040083. Published 2022 Oct 21. doi:10.3389/fphys.2022.1040083. Abstract The magnetic environment may influence the functioning of the cardiovascular system. It was reported that low- frequency and static magnetic fields affect hemodynamics, heart rate, and heart rate variability in animals and humans. Moreover, recent data suggest that magnetic fields affect the circadian rhythms of physiological processes. The influence of the magnetic environment on heart functionating during early development has been studied insufficiently. We utilized transparent zebrafish embryos to evaluate the effect of the hypomagnetic field on the characteristics of cardiac function using a noninvasive optical approach based on photoplethysmographic microscopic imaging. The embryos were exposed to the geomagnetic and hypomagnetic fields from the second to the 116th hour post fertilization under a 16 h light/8 h dark cycle or constant illumination. The exposure of embryos to the hypomagnetic field in both lighting modes led to increased embryo mortality, the appearance of abnormal phenotypes, and a significant increase in the embryo's heartbeat rate. The difference between maximal and minimal heartbeat intervals, maximal to minimal heartbeat intervals ratio, and the coefficient of variation of heartbeat rate were increased in the embryos exposed to the hypomagnetic field under constant illumination from 96 to 116 h post fertilization. The dynamics of heartbeat rate changes followed a circadian pattern in all studied groups except zebrafish exposed to the hypomagnetic field under constant illumination. The results demonstrate the importance of natural magnetic background for the early development of zebrafish. The possible mechanisms of observed effects are discussed. Open access paper: ncbi.nlm.nih.gov

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal

Effect directionharm

Populationzebrafish embryos

Sample sizeNot supplied

ExposureELF · from 2 to 116 hours post fertilization

Evidence strengthLowConfidence: 74% · Peer reviewed: yes

Main findings

Zebrafish embryos exposed to a hypomagnetic field (vs geomagnetic field) from 2 to 116 hours post fertilization showed increased embryo mortality, abnormal phenotypes, and a significant increase in heartbeat rate under both 16 h light/8 h dark and constant illumination. Under constant illumination, embryos exposed to the hypomagnetic field also showed increased heartbeat interval variability from 96 to 116 hours post fertilization, and the circadian pattern of heartbeat rate changes was absent in this group.

Outcomes measured

embryo mortality
abnormal phenotypes
heartbeat rate
heartbeat interval variability (max-min interval difference, max/min ratio, coefficient of variation)
circadian pattern of heartbeat rate changes

Limitations

Sample size not reported in provided abstract/metadata
Exposure intensity/field strength not reported in provided abstract/metadata
Details of randomization/blinding not reported in provided abstract/metadata

View raw extracted JSON

{
  "study_type": "animal",
  "exposure": {
    "band": "ELF",
    "source": "hypomagnetic field (reduced geomagnetic field)",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": "from 2 to 116 hours post fertilization"
  },
  "population": "zebrafish embryos",
  "sample_size": null,
  "outcomes": [
    "embryo mortality",
    "abnormal phenotypes",
    "heartbeat rate",
    "heartbeat interval variability (max-min interval difference, max/min ratio, coefficient of variation)",
    "circadian pattern of heartbeat rate changes"
  ],
  "main_findings": "Zebrafish embryos exposed to a hypomagnetic field (vs geomagnetic field) from 2 to 116 hours post fertilization showed increased embryo mortality, abnormal phenotypes, and a significant increase in heartbeat rate under both 16 h light/8 h dark and constant illumination. Under constant illumination, embryos exposed to the hypomagnetic field also showed increased heartbeat interval variability from 96 to 116 hours post fertilization, and the circadian pattern of heartbeat rate changes was absent in this group.",
  "effect_direction": "harm",
  "limitations": [
    "Sample size not reported in provided abstract/metadata",
    "Exposure intensity/field strength not reported in provided abstract/metadata",
    "Details of randomization/blinding not reported in provided abstract/metadata"
  ],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "hypomagnetic field",
    "geomagnetic field",
    "zebrafish embryos",
    "heartbeat rate",
    "heart rate variability",
    "circadian rhythm",
    "photoplethysmographic microscopic imaging",
    "early development"
  ],
  "suggested_hubs": []
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.3389/fphys.2022.1040083
PubMed: Not supplied

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