Hypomagnetic Field Exposure Affecting Gut Microbiota, Reactive Oxygen Species Levels, and Colonic Cell Proliferation in Mice

Bioelectromagnetics · 2022 · Harm · Low evidence

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HarmLow evidencePaper 663

Study snapshot

PublicationBioelectromagnetics · 2022

Study typeanimal

Reported directionHarm

Evidence ratingLow

Abstract

Hypomagnetic Field Exposure Affecting Gut Microbiota, Reactive Oxygen Species Levels, and Colonic Cell Proliferation in Mice Zhan A, Luo Y, Qin H, Lin W, Tian L. Hypomagnetic Field Exposure Affecting Gut Microbiota, Reactive Oxygen Species Levels, and Colonic Cell Proliferation in Mice. Bioelectromagnetics. 2022;10.1002/bem.22427. doi:10.1002/bem.22427 Abstract The gut microbiota has been considered one of the key factors in host health, which is influenced by many environmental factors. The geomagnetic field (GMF) represents one of the important environmental conditions for living organisms. Previous studies have shown that the elimination of GMF, the so-called hypomagnetic field (HMF), could affect the physiological functions and resistance to antibiotics of some microorganisms. However, whether long-term HMF exposure could alter the gut microbiota to some extent in mammals remains unclear. Here, we investigated the effects of long-term (8- and 12-week) HMF exposure on the gut microbiota in C57BL/6J mice. Our results clearly showed that 8-week HMF significantly affected the diversity and function of the mouse gut microbiota. Compared with the GMF group, the concentrations of short-chain fatty acids tended to decrease in the HMF group. Immunofluorescence analysis showed that HMF promoted colonic cell proliferation, concomitant with an increased level of reactive oxygen species (ROS). To our knowledge, this is the first in vivo finding that long-term HMF exposure could affect the mouse gut microbiota, ROS levels, and colonic cell proliferation in the colon. Moreover, the changes in gut microbiota can be restored by returning mice to the GMF environment, thus the possible harm to the microbiota caused by HMF exposure can be alleviated. pubmed.ncbi.nlm.nih.gov

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal

Effect directionharm

PopulationC57BL/6J mice

Sample sizeNot supplied

ExposureELF · long-term (8 and 12 weeks)

Evidence strengthLowConfidence: 74% · Peer reviewed: yes

Main findings

Long-term hypomagnetic field (HMF) exposure (8 and 12 weeks) altered mouse gut microbiota; 8-week HMF significantly affected gut microbiota diversity and function. Short-chain fatty acid concentrations tended to decrease under HMF versus geomagnetic field (GMF). HMF promoted colonic cell proliferation with increased reactive oxygen species (ROS), and microbiota changes were reported to be restorable after returning to GMF.

Outcomes measured

Gut microbiota diversity
Gut microbiota function
Short-chain fatty acid concentrations
Reactive oxygen species (ROS) levels
Colonic cell proliferation
Reversibility of microbiota changes after return to geomagnetic field

Limitations

Sample size not reported in abstract
Exposure intensity/field strength not reported in abstract
Specific microbiota taxa changes not detailed in abstract
Statistical details for some outcomes (e.g., SCFAs 'tended to decrease') not fully specified

View raw extracted JSON

{
  "study_type": "animal",
  "exposure": {
    "band": "ELF",
    "source": "hypomagnetic field (elimination of geomagnetic field)",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": "long-term (8 and 12 weeks)"
  },
  "population": "C57BL/6J mice",
  "sample_size": null,
  "outcomes": [
    "Gut microbiota diversity",
    "Gut microbiota function",
    "Short-chain fatty acid concentrations",
    "Reactive oxygen species (ROS) levels",
    "Colonic cell proliferation",
    "Reversibility of microbiota changes after return to geomagnetic field"
  ],
  "main_findings": "Long-term hypomagnetic field (HMF) exposure (8 and 12 weeks) altered mouse gut microbiota; 8-week HMF significantly affected gut microbiota diversity and function. Short-chain fatty acid concentrations tended to decrease under HMF versus geomagnetic field (GMF). HMF promoted colonic cell proliferation with increased reactive oxygen species (ROS), and microbiota changes were reported to be restorable after returning to GMF.",
  "effect_direction": "harm",
  "limitations": [
    "Sample size not reported in abstract",
    "Exposure intensity/field strength not reported in abstract",
    "Specific microbiota taxa changes not detailed in abstract",
    "Statistical details for some outcomes (e.g., SCFAs 'tended to decrease') not fully specified"
  ],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "hypomagnetic field",
    "geomagnetic field",
    "gut microbiota",
    "short-chain fatty acids",
    "reactive oxygen species",
    "colonic cell proliferation",
    "C57BL/6J mice"
  ],
  "suggested_hubs": [
    {
      "slug": "elF-geomagnetic-hypomagnetic",
      "weight": 0.86,
      "reason": "Study examines elimination of geomagnetic field (hypomagnetic field) exposure and biological effects in mice."
    }
  ]
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1002/bem.22427
PubMed: 36434792

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