Effects of Intermediate Frequency (150 kHz) Electromagnetic Radiation on the Vital Organs of Female Sprague Dawley Rats

2023 · Mixed · Low evidence

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MixedLow evidencePaper 545

Most major organs showed no significant detectable effects in either group. Gross and histopathological examinations indicated inflammatory changes in the liver and lungs in the EMR group without significant biochemical/haematological manifestations. The EMR …

Study snapshot

Publicationmanual · 2023

Study typeanimal

Reported directionMixed

Evidence ratingLow

Abstract

Effects of Intermediate Frequency (150 kHz) Electromagnetic Radiation on the Vital Organs of Female Sprague Dawley Rats Sundaram V, Mohammed S, Cockburn BN, Srinivasan MR, Venkata CRA, Johnson J, Gilkes L, Jones KR, Zyuzikov N. Effects of Intermediate Frequency (150 kHz) Electromagnetic Radiation on the Vital Organs of Female Sprague Dawley Rats. Biology (Basel). 2023 Feb 14;12(2):310. doi: 10.3390/biology12020310. Abstract Exposure to electromagnetic radiation (EMR) from intermediate frequency sources has increased exponentially in recent years. The consequences of this exposure on biological systems are prompting scientists to study the effects on human health. This current study aimed to determine the effects of intermediate frequency (150 kHz) EMR exposure on the vital organs of female Sprague Dawley rats. The EMR group (n = 10 animals) was exposed to a frequency of 150 kHz with an intensity of 65 ± 15 μW/cm2 for two months. The control group (n = 10 animals) was exposed to an intensity of 35 ± 15 nW/cm2. Haematological, histochemical, gross, and histopathological profiles of all major organs of all animals were then performed using standard procedures. All major organs generally showed no significant detectable effects in either the control or EMR groups. However, gross and histopathological examinations revealed the effects of EMR on the liver and lungs, which showed inflammatory changes without significant biochemical/haematological manifestations. In addition, a significant increase in serum sodium level and a decrease in serum urea level were also observed in the EMR group. It can be concluded that the current frequency and duration of exposure trigger the changes in the liver and lungs but are not sufficient to cause clinical and functional manifestations. Therefore, a long-term exposure study might be helpful to determine the effects of 150 kHz IF EMR on these organs. Open access paper: mdpi.com

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal

Effect directionmixed

PopulationFemale Sprague Dawley rats

Sample size20

Exposureintermediate frequency · 0.15 MHz · two months

Evidence strengthLowConfidence: 78% · Peer reviewed: yes

Main findings

Outcomes measured

Gross organ findings
Histopathology of major organs
Histochemical profiles
Haematological profiles
Serum sodium level
Serum urea level
Biochemical manifestations (not specified)

Limitations

Short duration (two months) with suggestion that longer-term exposure may be needed
Small group sizes (n=10 per group)

View raw extracted JSON

{
  "study_type": "animal",
  "exposure": {
    "band": "intermediate frequency",
    "source": "intermediate frequency sources",
    "frequency_mhz": 0.15,
    "sar_wkg": null,
    "duration": "two months"
  },
  "population": "Female Sprague Dawley rats",
  "sample_size": 20,
  "outcomes": [
    "Gross organ findings",
    "Histopathology of major organs",
    "Histochemical profiles",
    "Haematological profiles",
    "Serum sodium level",
    "Serum urea level",
    "Biochemical manifestations (not specified)"
  ],
  "main_findings": "Most major organs showed no significant detectable effects in either group. Gross and histopathological examinations indicated inflammatory changes in the liver and lungs in the EMR group without significant biochemical/haematological manifestations. The EMR group also showed a significant increase in serum sodium and a decrease in serum urea.",
  "effect_direction": "mixed",
  "limitations": [
    "Short duration (two months) with suggestion that longer-term exposure may be needed",
    "Small group sizes (n=10 per group)"
  ],
  "evidence_strength": "low",
  "confidence": 0.78,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "intermediate frequency",
    "150 kHz",
    "electromagnetic radiation",
    "Sprague Dawley rats",
    "liver",
    "lungs",
    "inflammation",
    "histopathology",
    "serum sodium",
    "serum urea"
  ],
  "suggested_hubs": [
    {
      "slug": "intermediate-frequency",
      "weight": 0.9,
      "reason": "Study tests intermediate frequency EMR exposure at 150 kHz in an animal model."
    }
  ]
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.3390/biology12020310
PubMed: Not supplied

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