Effects of 2600 Mhz RF Radiation and Melatonin on Skin and Liver Tissue Hydroxyprolin Levels of Male Rats

2023 · Mixed · Low evidence

← Research stream

MixedLow evidencePaper 504

Skin tissue Hyp levels decreased significantly in RFR-treated groups versus control and sham (p<0.05). Skin Hyp levels also decreased significantly in the RFR+melatonin group versus control, sham, and sham+melatonin; liver tissue Hyp levels showed no changes.

Study snapshot

Publicationmanual · 2023

Study typeanimal

Reported directionMixed

Evidence ratingLow

Abstract

Effects of 2600 Mhz RF Radiation and Melatonin on Skin and Liver Tissue Hydroxyprolin Levels of Male Rats Oruc S, Delen K, Yardim A, Aral BS, Kuzay D, Ceyman CM, Kaplanoglu GT. Effects of 2600 Mhz Radiofrequency Radiation and Melatonin on Skin and Liver Tissue Hydroxyprolin Levels of Male Rats. Gazi Med J 2023; 34 (2): 141-144. Abstract Objective: In the present study, the effect of 2600 MHz radiofrequency radiation (RFR) exposure, and melatonin treatment on skin and liver tissue hydroxyproline (Hyp) levels were evaluated. Methods: In the study, 2600 MHz RFR application was performed by Rohde & Schwartz Radiofrequency signal generator via ETS-Lindgren horn antenna. 36 Wistar albino male rats were randomly divided into 6 groups (n = 6); Control, sham, RFR, control + Melatonin, Sham + Melatonin, RFR+ Melatonin. RFR was applied to the related groups for 30 days (5 days/week) for 30 minutes a day. Average electric field value is 21.74 V / m. Melatonin groups were subcutaneously injected with melatonin (10 mg/kg) for 30 days. At the end of the experiment, Hyp levels were measured in the skin and liver tissues. Results: Hyp levels in skin tissue decreased significantly in RFR treated groups compared to the control and sham groups (p <0.05). Also, Hyp levels in skin tissue decreased significantly in RFR + melatonin treated group compared to the control, sham and sham+melatonin groups. No changes in Hyp levels in liver tissue were determined. Conclusion:In this study, RFR exposure leads to significant changes in skin Hyp levels but not liver tissue. This effect is thought to be due to the closer the skin tissue to the surface. Open access paper: medicaljournal.gazi.edu.tr medicaljournal.gazi.edu.tr

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal

Effect directionmixed

PopulationWistar albino male rats

Sample size36

ExposureRF · 2600 MHz · 30 days (5 days/week), 30 minutes/day

Evidence strengthLowConfidence: 78% · Peer reviewed: unknown

Main findings

Outcomes measured

Skin tissue hydroxyproline (Hyp) levels
Liver tissue hydroxyproline (Hyp) levels

Limitations

No SAR reported (only average electric field value reported)
Small group sizes (n=6 per group)
Outcome limited to hydroxyproline levels in skin and liver; no other endpoints described in abstract

View raw extracted JSON

{
  "study_type": "animal",
  "exposure": {
    "band": "RF",
    "source": "signal generator via horn antenna",
    "frequency_mhz": 2600,
    "sar_wkg": null,
    "duration": "30 days (5 days/week), 30 minutes/day"
  },
  "population": "Wistar albino male rats",
  "sample_size": 36,
  "outcomes": [
    "Skin tissue hydroxyproline (Hyp) levels",
    "Liver tissue hydroxyproline (Hyp) levels"
  ],
  "main_findings": "Skin tissue Hyp levels decreased significantly in RFR-treated groups versus control and sham (p<0.05). Skin Hyp levels also decreased significantly in the RFR+melatonin group versus control, sham, and sham+melatonin; liver tissue Hyp levels showed no changes.",
  "effect_direction": "mixed",
  "limitations": [
    "No SAR reported (only average electric field value reported)",
    "Small group sizes (n=6 per group)",
    "Outcome limited to hydroxyproline levels in skin and liver; no other endpoints described in abstract"
  ],
  "evidence_strength": "low",
  "confidence": 0.78,
  "peer_reviewed_likely": "unknown",
  "keywords": [
    "2600 MHz",
    "radiofrequency radiation",
    "RFR",
    "melatonin",
    "hydroxyproline",
    "skin",
    "liver",
    "rat",
    "electric field",
    "horn antenna"
  ],
  "suggested_hubs": [
    {
      "slug": "5g-policy",
      "weight": 0.32,
      "reason": "Exposure frequency (2600 MHz) overlaps with cellular/4G-LTE bands sometimes discussed alongside 5G-related RF topics."
    }
  ]
}

AI can be wrong. Always verify against the paper.

AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: Not supplied
PubMed: Not supplied

Read the original paper →

Related papers

← Back to the Research Library