Glioblastoma behavior study under different frequency electromagnetic field

2023 · Benefit · Low evidence

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BenefitLow evidencePaper 335

Finite element simulations of a mitotic cell predicted a local electric field increase in the cleavage furrow region. Cell experiments reported reduced glioma cell proliferation and migration under TTFields in a frequency- and field-strength-dependent manner.

Study snapshot

Publicationmanual · 2023

Study typeother

Reported directionBenefit

Evidence ratingLow

Abstract

Glioblastoma behavior study under different frequency electromagnetic field Xiang XW, Liu HT, Tao XN, Zeng YL, Liu J, Wang C, Yu SX, Zhao H, Liu YJ, Liu KF. Glioblastoma behavior study under different frequency electromagnetic field. iScience. 2023 Nov 23;26(12):108575. doi: 10.1016/j.isci.2023.108575. Abstract The tumor-treating fields (TTFields) technology has revolutionized the management of recurrent and newly diagnosed glioblastoma (GBM) cases. To ameliorate this treatment modality for GBM and other oncological conditions, it is necessary to understand the biophysical principles of TTFields better. In this study, we further analyzed the mechanism of the electromagnetic exposure with varying frequencies and electric field strengths on cells in mitosis, specifically in telophase. In reference to previous studies, an intuitive finite element model of the mitotic cell was built for electromagnetic simulations, predicting a local increase in the cleavage furrow region, which may help explain TTFields' anti-proliferative effects. Cell experiments confirmed that the reduction in proliferation and migration of glioma cell by TTFields was in a frequency- and field-strength-dependent manner. This work provides unique insights into the selection of frequencies in the anti-proliferative effect of TTFields on tumors, which could improve the application of TTFields. Open access paper: cell.com

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeother

Effect directionbenefit

PopulationNot supplied

Sample sizeNot supplied

ExposureNot supplied

Evidence strengthLowConfidence: 74% · Peer reviewed: yes

Main findings

Outcomes measured

glioma cell proliferation
glioma cell migration
electric field distribution in mitotic cell (telophase), including cleavage furrow region

Limitations

Specific TTFields frequencies and electric field strengths are not provided in the abstract.
No sample size or detailed experimental design information is provided in the abstract.
Outcomes are described for cell experiments/simulations; no human clinical outcomes are reported in the abstract.

View raw extracted JSON

{
  "study_type": "other",
  "exposure": {
    "band": null,
    "source": "tumor-treating fields (TTFields)",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": null
  },
  "population": null,
  "sample_size": null,
  "outcomes": [
    "glioma cell proliferation",
    "glioma cell migration",
    "electric field distribution in mitotic cell (telophase), including cleavage furrow region"
  ],
  "main_findings": "Finite element simulations of a mitotic cell predicted a local electric field increase in the cleavage furrow region. Cell experiments reported reduced glioma cell proliferation and migration under TTFields in a frequency- and field-strength-dependent manner.",
  "effect_direction": "benefit",
  "limitations": [
    "Specific TTFields frequencies and electric field strengths are not provided in the abstract.",
    "No sample size or detailed experimental design information is provided in the abstract.",
    "Outcomes are described for cell experiments/simulations; no human clinical outcomes are reported in the abstract."
  ],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "glioblastoma",
    "GBM",
    "tumor-treating fields",
    "TTFields",
    "electromagnetic exposure",
    "frequency dependence",
    "electric field strength",
    "finite element model",
    "mitosis",
    "telophase",
    "cleavage furrow",
    "cell proliferation",
    "cell migration"
  ],
  "suggested_hubs": [
    {
      "slug": "cancer-ttfields",
      "weight": 0.95,
      "reason": "Study focuses on tumor-treating fields (TTFields) and anti-proliferative effects in glioma/GBM models."
    }
  ]
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1016/j.isci.2023.108575
PubMed: Not supplied

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