Emerging cancer therapies: targeting physiological networks and cellular bioelectrical differences with non-thermal systemic electromagnetic fields in the human body - a comprehensive review

Front Netw Physiol · 2024 · Benefit · Insufficient evidence

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BenefitInsufficient evidencePaper 303

The review states that non-thermal systemic radiofrequency electromagnetic fields in oncology have produced sustained responses and improved quality of life in cancer patients with minimal side effects, and argues this approach shows promising therapeutic res…

Study snapshot

PublicationFront Netw Physiol · 2024

Study typereview

Reported directionBenefit

Evidence ratingInsufficient

Abstract

Emerging cancer therapies: targeting physiological networks and cellular bioelectrical differences with non-thermal systemic electromagnetic fields in the human body – a comprehensive review Costa FP, Wiedenmann B, Schöll E, Tuszynski J. Emerging cancer therapies: targeting physiological networks and cellular bioelectrical differences with non-thermal systemic electromagnetic fields in the human body – a comprehensive review. Frontiers in Network Physiology. Vol. 4, 2024. doi: 10.3389/fnetp.2024.1483401. Abstract A steadily increasing number of publications support the concept of physiological networks, and how cellular bioelectrical properties drive cell proliferation and cell synchronization. All cells, especially cancer cells, are known to possess characteristic electrical properties critical for physiological behavior, with major differences between normal and cancer cell counterparts. This opportunity can be explored as a novel treatment modality in Oncology. Cancer cells exhibit autonomous oscillations, deviating from normal rhythms. In this context, a shift from a static view of cellular processes is required for a better understanding of the dynamic connections between cellular metabolism, gene expression, cell signaling and membrane polarization as states in constant flux in realistic human models. In oncology, radiofrequency electromagnetic fields have produced sustained responses and improved quality of life in cancer patients with minimal side effects. This review aims to show how non-thermal systemic radiofrequency electromagnetic fields leads to promising therapeutic responses at cellular and tissue levels in humans, supporting this newly emerging cancer treatment modality with early favorable clinical experience specifically in advanced cancer. Open access paper: frontiersin.org

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typereview

Effect directionbenefit

PopulationHumans (cancer patients; advanced cancer mentioned)

Sample sizeNot supplied

ExposureRF

Evidence strengthInsufficientConfidence: 66% · Peer reviewed: yes

Main findings

Outcomes measured

therapeutic response in cancer
quality of life
side effects/tolerability
cellular and tissue-level responses

Limitations

No specific study designs, sample sizes, exposure parameters (frequency/SAR/duration), or quantitative effect estimates are provided in the abstract.
Claims are framed broadly as a comprehensive review and rely on unspecified underlying publications/clinical experience.

View raw extracted JSON

{
  "study_type": "review",
  "exposure": {
    "band": "RF",
    "source": "therapeutic systemic radiofrequency electromagnetic fields (non-thermal)",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": null
  },
  "population": "Humans (cancer patients; advanced cancer mentioned)",
  "sample_size": null,
  "outcomes": [
    "therapeutic response in cancer",
    "quality of life",
    "side effects/tolerability",
    "cellular and tissue-level responses"
  ],
  "main_findings": "The review states that non-thermal systemic radiofrequency electromagnetic fields in oncology have produced sustained responses and improved quality of life in cancer patients with minimal side effects, and argues this approach shows promising therapeutic responses at cellular and tissue levels with early favorable clinical experience in advanced cancer.",
  "effect_direction": "benefit",
  "limitations": [
    "No specific study designs, sample sizes, exposure parameters (frequency/SAR/duration), or quantitative effect estimates are provided in the abstract.",
    "Claims are framed broadly as a comprehensive review and rely on unspecified underlying publications/clinical experience."
  ],
  "evidence_strength": "insufficient",
  "confidence": 0.66,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "cancer therapy",
    "oncology",
    "physiological networks",
    "bioelectricity",
    "cell membrane polarization",
    "non-thermal",
    "systemic radiofrequency electromagnetic fields",
    "radiofrequency EMF",
    "quality of life",
    "advanced cancer"
  ],
  "suggested_hubs": []
}

AI can be wrong. Always verify against the paper.

AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.3389/fnetp.2024.1483401
PubMed: Not supplied

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