RF Safe

Long-term residential magnetic field exposure and neurodegenerative disease mortality: An 18-year nationwide cohort study in Switzerland

Environ Int · 2026 · Harm · Moderate evidence

← Research stream
HarmModerate evidencePaper 6672

Long-term ELF-MF exposure from high-voltage power lines was associated with increased mortality risk from Alzheimer's disease and other types of dementia. Associations with railway line exposure were weaker and attenuated after adjustment. No associations wer…

Study snapshot

PublicationEnviron Int · 2026
Study typecohort
Reported directionHarm
Evidence ratingModerate

Abstract

Background: Epidemiological evidence on the association between extremely low-frequency magnetic fields (ELF-MF) exposure and neurodegenerative diseases (NDD) remains inconsistent. Few population-based studies using exposure from high-voltage power lines (HVPL) have found mixed findings, and none have yet considered exposure from railway lines. Methods: We followed 3,555,064 adults from the Swiss National Cohort (2001-2018), contributing 55.4 million person-years. Long-term ELF-MF exposure from HVPL (50 Hz) and railway lines (16.7 Hz) was modelled using validated proximity models and updated over four intervals (2001-2005, 2006-2010, 2011-2015, 2016-2018). Long-term ELF-MF exposure was calculated as a time-weighted average exposure over 10-year windows preceding each interval. Cox proportional hazards models estimated hazard ratios (HRs) for mortality from Alzheimer's disease (AD), other types of dementia (OTD), amyotrophic lateral sclerosis (ALS), Parkinson's disease (PD), and multiple sclerosis (MS), adjusting for sociodemographic and environmental co-exposures. Results: During follow-up, 146,655 NDD deaths occurred. Less than 1% of the population was exposed to long-term ELF-MF ≥ 0.3 µT from HVPL and 2.4% from railway lines. HVPL exposure was positively associated with mortality from AD (HR per 1 µT increase in exposure = 1.54; 95% CI: 1.23-1.92) and OTD (HR = 1.31; 95% CI: 1.13-1.52). Associations for railway exposure were weaker and attenuated after adjusting for environmental co-exposures. No associations were observed for ALS, PD, or MS. Conclusions: Long-term ELF-MF exposure was associated with higher dementia mortality risk in the general population, but not with ALS, PD, or MS. Causal inference remains limited by the absence of established biological mechanisms. Effect: harm

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typecohort
Effect directionharm
Population3,555,064 adults from the Swiss National Cohort (2001-2018)
Sample size3555064
ExposureELF · long-term, 10-year time-weighted average exposure
Evidence strengthModerateConfidence: 70% · Peer reviewed: yes

Main findings

Long-term ELF-MF exposure from high-voltage power lines was associated with increased mortality risk from Alzheimer's disease and other types of dementia. Associations with railway line exposure were weaker and attenuated after adjustment. No associations were found for ALS, Parkinson's disease, or multiple sclerosis.

Outcomes measured

  • mortality from Alzheimer's disease
  • mortality from other types of dementia
  • mortality from amyotrophic lateral sclerosis
  • mortality from Parkinson's disease
  • mortality from multiple sclerosis

Limitations

  • Observational study design limits causal inference
  • Absence of established biological mechanisms
  • Exposure assessment based on proximity models may have measurement error
  • Less than 1% exposed to high ELF-MF from HVPL, limiting generalizability
View raw extracted JSON
{
  "study_type": "cohort",
  "exposure": {
    "band": "ELF",
    "source": "high-voltage power lines and railway lines",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": "long-term, 10-year time-weighted average exposure"
  },
  "population": "3,555,064 adults from the Swiss National Cohort (2001-2018)",
  "sample_size": 3555064,
  "outcomes": [
    "mortality from Alzheimer's disease",
    "mortality from other types of dementia",
    "mortality from amyotrophic lateral sclerosis",
    "mortality from Parkinson's disease",
    "mortality from multiple sclerosis"
  ],
  "main_findings": "Long-term ELF-MF exposure from high-voltage power lines was associated with increased mortality risk from Alzheimer's disease and other types of dementia. Associations with railway line exposure were weaker and attenuated after adjustment. No associations were found for ALS, Parkinson's disease, or multiple sclerosis.",
  "effect_direction": "harm",
  "limitations": [
    "Observational study design limits causal inference",
    "Absence of established biological mechanisms",
    "Exposure assessment based on proximity models may have measurement error",
    "Less than 1% exposed to high ELF-MF from HVPL, limiting generalizability"
  ],
  "evidence_strength": "moderate",
  "confidence": 0.7,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "ELF magnetic fields",
    "neurodegenerative diseases",
    "dementia",
    "Alzheimer's disease",
    "cohort study",
    "mortality",
    "high-voltage power lines",
    "railway lines"
  ],
  "suggested_hubs": [
    {
      "slug": "occupational-exposure",
      "weight": 0.3,
      "reason": "Study of ELF magnetic field exposure from power lines and railway lines relevant to environmental and occupational exposure."
    }
  ]
}
AI can be wrong. Always verify against the paper.

AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1016/j.envint.2026.110145
PubMed: 41691953

Read the original paper →

Related papers

← Back to the Research Library