Microwave effects on acetylcholine-induced channels in cultured chick myotubes

Bioelectromagnetics · 1988 · Harm · Low evidence

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HarmLow evidencePaper 6669

During exposure to low-power microwaves, the frequency of ACh-activated single-channel openings decreased and the ACh-induced total current showed a faster falling phase. Channel open time and conductance were reported as not affected; the authors conclude mi…

Study snapshot

PublicationBioelectromagnetics · 1988

Study typein_vitro

Reported directionHarm

Evidence ratingLow

Abstract

The behavior of cultured myotubes from chick embryos exposed to microwaves has been experimentally analyzed. Recordings of acetylcholine-induced currents have been obtained via patch-clamp techniques using both cell-attached (single-channel current recording) and whole-cell (total current recording) configurations. During the exposure to low-power microwaves the frequency of the ACh-activated single channel openings decreased, while the ACh-induced total current showed a faster falling phase. Channel open time and conductance were not affected by microwave irradiation. It is concluded that the exposure to microwaves increases the rate of desensitization and decreases the channel opening probability. The nonthermal origin and the molecular interaction mechanisms governing these electromagnetic-induced effects are discussed.

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typein_vitro

Effect directionharm

PopulationCultured myotubes from chick embryos (chick myotubes)

Sample sizeNot supplied

Exposuremicrowave

Evidence strengthLowConfidence: 74% · Peer reviewed: yes

Main findings

Outcomes measured

Acetylcholine (ACh)-activated single-channel opening frequency
ACh-induced total current falling phase (desensitization rate)
Channel open time
Channel conductance
Channel opening probability

Limitations

Exposure parameters (e.g., frequency, SAR, duration) not provided in the abstract
In vitro model (cultured chick embryo myotubes), limiting direct generalization to humans or in vivo conditions
Sample size and statistical details not reported in the abstract

View raw extracted JSON

{
  "study_type": "in_vitro",
  "exposure": {
    "band": "microwave",
    "source": null,
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": null
  },
  "population": "Cultured myotubes from chick embryos (chick myotubes)",
  "sample_size": null,
  "outcomes": [
    "Acetylcholine (ACh)-activated single-channel opening frequency",
    "ACh-induced total current falling phase (desensitization rate)",
    "Channel open time",
    "Channel conductance",
    "Channel opening probability"
  ],
  "main_findings": "During exposure to low-power microwaves, the frequency of ACh-activated single-channel openings decreased and the ACh-induced total current showed a faster falling phase. Channel open time and conductance were reported as not affected; the authors conclude microwaves increased desensitization rate and decreased channel opening probability.",
  "effect_direction": "harm",
  "limitations": [
    "Exposure parameters (e.g., frequency, SAR, duration) not provided in the abstract",
    "In vitro model (cultured chick embryo myotubes), limiting direct generalization to humans or in vivo conditions",
    "Sample size and statistical details not reported in the abstract"
  ],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "microwaves",
    "low-power",
    "acetylcholine-induced currents",
    "ACh receptor channels",
    "patch-clamp",
    "cell-attached",
    "whole-cell",
    "single-channel openings",
    "desensitization",
    "chick myotubes",
    "in vitro"
  ],
  "suggested_hubs": []
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1002/bem.2250090406
PubMed: 2461204

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