THE INFLUENCE OF THE SELECTED CATALYSTS AND MICROWAVE RADIATION ON THE COURSE OF OBTAINING POLY-e-CAPROLACTONE AS A BIODEGRADABLE CARRIER OF MEDICINAL SUBSTANCES.

Acta poloniae pharmaceutica · 2017 · Benefit · Insufficient evidence

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BenefitInsufficient evidencePaper 6602

In ring-opening polymerization of ε-caprolactone catalyzed by organic acids, citric acid produced substantially higher molecular weight polymer compared with other catalysts. Higher average molecular weights were also obtained when reactions were conducted un…

Study snapshot

PublicationActa poloniae pharmaceutica · 2017

Study typeother

Reported directionBenefit

Evidence ratingInsufficient

Abstract

The ring opening polymerization of ε-caprolactone catalyzed by organic acids had been studied. The aim of this study was to develop and optimize a process for obtaining poly-ε-caprolactone of high purity intend- ed for use as a drug carrier, with consideration of the impct of the monomer-catalyst ratio on the product parameters, the temperature impact and the impact of the type of catalyst on the product properties. The studies also aim to determine the possible positive effect of microwave radiation on the course of the reaction. The structures of the synthesized compounds were proven by 'H NMR spectroscopy. The average molecular weight of the obtained polymer particles was estimated based on the relations of the 'H NMR signal integrations. In the reaction catalyzed by citric acid the product was characterized by a substantially higher molecular weight compared to the analogous reaction using another type of catalysts. Higher average molecular weights were obtained by conducting the reactions under microwave radiation.

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeother

Effect directionbenefit

PopulationNot supplied

Sample sizeNot supplied

Exposuremicrowave

Evidence strengthInsufficientConfidence: 74% · Peer reviewed: yes

Main findings

Outcomes measured

poly-ε-caprolactone molecular weight
polymer product properties/purity (process optimization)

Limitations

No microwave exposure parameters (e.g., frequency, power, duration) reported in the abstract.
No sample size or number of experiments reported in the abstract.
Outcomes are chemical/process measures rather than biological or health endpoints.

View raw extracted JSON

{
  "study_type": "other",
  "exposure": {
    "band": "microwave",
    "source": null,
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": null
  },
  "population": null,
  "sample_size": null,
  "outcomes": [
    "poly-ε-caprolactone molecular weight",
    "polymer product properties/purity (process optimization)"
  ],
  "main_findings": "In ring-opening polymerization of ε-caprolactone catalyzed by organic acids, citric acid produced substantially higher molecular weight polymer compared with other catalysts. Higher average molecular weights were also obtained when reactions were conducted under microwave radiation.",
  "effect_direction": "benefit",
  "limitations": [
    "No microwave exposure parameters (e.g., frequency, power, duration) reported in the abstract.",
    "No sample size or number of experiments reported in the abstract.",
    "Outcomes are chemical/process measures rather than biological or health endpoints."
  ],
  "evidence_strength": "insufficient",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "microwave radiation",
    "ring-opening polymerization",
    "ε-caprolactone",
    "poly-ε-caprolactone",
    "citric acid",
    "catalyst",
    "1H NMR",
    "molecular weight",
    "drug carrier",
    "biodegradable polymer"
  ],
  "suggested_hubs": []
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: Not supplied
PubMed: 29474778

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