[Morinda officialis how extract improves microwave-induced reproductive impairment in male rats].

Zhonghua nan ke xue = National journal of andrology · 2013 · Mixed · Low evidence

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MixedLow evidencePaper 6535

Study snapshot

PublicationZhonghua nan ke xue = National journal of andrology · 2013

Study typeanimal

Reported directionMixed

Evidence ratingLow

Abstract

OBJECTIVE: To investigate the effects of different concentrations of Morinda Officialis How (MOH) extracts on microwave radiation-induced injury to the spermatogenic function of male rats. METHODS: Forty SD male rats were equally divided into four groups: control, microwave injury model, aqueous extract of MOH treatment, and alcohol extract of MOH treatment. Models of microwave-induced injury were made by exposing the rats to microwave radiation from a microwave signal generator (900 MHz 1.0 W) at 218 microm/cm2, 12 h/d, for 2 weeks. The model rats of the two treatment groups were intragastrically given aqueous extract and alcohol extract of MOH, respectively, both at 20 g per kg per day for 2 weeks. Then we observed the growth, capture incubation period (CIP), capture times (CT), changes in testicular and epididymal weight and morphology, sperm concentration and malformation, and levels of serum testosterone. RESULTS: Compared with the controls, the rats of the model group showed a slightly reduced body weight, markedly prolonged CIP and decreased CT (P < 0.05), significantly reduced sperm concentration (P < 0.05) and remarkably in- creased sperm malformation (P < 0.05), but no statistically significant differences in the testosterone level. The two treatment groups exhibited obviously decreased body weight, CIP and sperm malformation compared with the control group (P < 0.05) but markedly increased CT, sperm concentration and testosterone level as compared with the models (P < 0.05). The microwave radiation-induced testis injury was repaired perfectly in the two treatment groups, the epididymal ducts filled with sperm and cast-off cells. CONCLUSION: Both aqueous and alcohol extracts of MOH can promote spermatogenesis and repair of reproductive injury induced by microwave radiation.

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AI evidence extraction

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Study typeanimal

Effect directionmixed

PopulationMale Sprague-Dawley rats

Sample size40

ExposureRF · 900 MHz · 12 h/d for 2 weeks

Evidence strengthLowConfidence: 78% · Peer reviewed: yes

Main findings

Rats exposed to 900 MHz microwave radiation (1.0 W; 218 microm/cm2; 12 h/d for 2 weeks) showed prolonged CIP, decreased CT, reduced sperm concentration, and increased sperm malformation versus controls, with no statistically significant difference in testosterone. In rats with microwave-induced injury, treatment with aqueous or alcohol Morinda Officialis How extract (20 g/kg/day for 2 weeks) was associated with increased CT, sperm concentration, and testosterone and decreased CIP and sperm malformation compared with the model group, and testis injury was described as repaired in treatment groups.

Outcomes measured

Body weight
Capture incubation period (CIP)
Capture times (CT)
Testicular weight and morphology
Epididymal weight and morphology
Sperm concentration
Sperm malformation
Serum testosterone

Limitations

No SAR reported
Exposure metric reported as 218 microm/cm2 without further dosimetry details
Only male rats; generalizability to humans unclear
Treatment effects confound interpretation of exposure-only effects

View raw extracted JSON

{
  "study_type": "animal",
  "exposure": {
    "band": "RF",
    "source": "microwave signal generator",
    "frequency_mhz": 900,
    "sar_wkg": null,
    "duration": "12 h/d for 2 weeks"
  },
  "population": "Male Sprague-Dawley rats",
  "sample_size": 40,
  "outcomes": [
    "Body weight",
    "Capture incubation period (CIP)",
    "Capture times (CT)",
    "Testicular weight and morphology",
    "Epididymal weight and morphology",
    "Sperm concentration",
    "Sperm malformation",
    "Serum testosterone"
  ],
  "main_findings": "Rats exposed to 900 MHz microwave radiation (1.0 W; 218 microm/cm2; 12 h/d for 2 weeks) showed prolonged CIP, decreased CT, reduced sperm concentration, and increased sperm malformation versus controls, with no statistically significant difference in testosterone. In rats with microwave-induced injury, treatment with aqueous or alcohol Morinda Officialis How extract (20 g/kg/day for 2 weeks) was associated with increased CT, sperm concentration, and testosterone and decreased CIP and sperm malformation compared with the model group, and testis injury was described as repaired in treatment groups.",
  "effect_direction": "mixed",
  "limitations": [
    "No SAR reported",
    "Exposure metric reported as 218 microm/cm2 without further dosimetry details",
    "Only male rats; generalizability to humans unclear",
    "Treatment effects confound interpretation of exposure-only effects"
  ],
  "evidence_strength": "low",
  "confidence": 0.78,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "microwave radiation",
    "900 MHz",
    "male rats",
    "spermatogenesis",
    "reproductive toxicity",
    "sperm concentration",
    "sperm malformation",
    "testosterone",
    "Morinda Officialis How extract"
  ],
  "suggested_hubs": [
    {
      "slug": "rf-male-fertility",
      "weight": 0.86,
      "reason": "Animal study of 900 MHz microwave exposure assessing sperm parameters and reproductive outcomes."
    }
  ]
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: Not supplied
PubMed: 23678715

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