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Inhibitory Effects of Microwave Radiation on LPS-Induced NFκB Expression in THP-1 Monocytes.

The Chinese journal of physiology · 2012 · Benefit · Very low evidence

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BenefitVery low evidencePaper 6516

In PMA- and LPS-stimulated THP-1 monocytes, NFκB levels increased, and exposure to microwave radiation was reported to decrease NFκB expression. The authors conclude microwave radiation inhibited activity/functions of stimulated THP-1 monocytes.

Study snapshot

PublicationThe Chinese journal of physiology · 2012
Study typein_vitro
Reported directionBenefit
Evidence ratingVery low

Abstract

Microwave radiations can be encountered regularly in daily lives. When WHO announced that microwave radiations were a kind of environmental energy which interfere with the physiological functions of the human body, great concerns have been raised over the damages microwave frequencies can do to human physiology. The immunological performance and the activities of the cellular inflammatory factor NFκB have been closely related in monocyte. Due to the effect of phorbol 12-myristate 13-acetate (PMA) on THP-1 monocytes, THP-1 monocytes would differentiate into macrophages and would then react with lipopolysaccharides (LPS), and the amount of NFκB increased in the THP-1 monocytes. Expression of cytokine is affected when cells are exposed to a frequency of 2450 MHz and at 900 W. Thus, in our experiments, an observation was made when THP-1 monocytes were stimulated with PMA and LPS to differentiate into macrophage, the amount of NFκB in cells increased exponentially, and the levels of NFκB expression were decreased by the exposure of microwave radiation. In conclusion, microwave radiations were found to inhibit the activity functions of THP-1 monocytes stimulated with PMA and LPS.

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typein_vitro
Effect directionbenefit
PopulationTHP-1 monocytes (stimulated with PMA and LPS; differentiated toward macrophage-like cells)
Sample sizeNot supplied
Exposuremicrowave · 2450 MHz
Evidence strengthVery lowConfidence: 74% · Peer reviewed: yes

Main findings

In PMA- and LPS-stimulated THP-1 monocytes, NFκB levels increased, and exposure to microwave radiation was reported to decrease NFκB expression. The authors conclude microwave radiation inhibited activity/functions of stimulated THP-1 monocytes.

Outcomes measured

  • NFκB expression/activity in THP-1 monocytes under PMA+LPS stimulation
  • Cytokine expression (mentioned generally)

Limitations

  • No exposure duration reported
  • No SAR or dosimetry details reported (only frequency and power stated)
  • Sample size not reported
  • Outcome measurement methods not described in the abstract
  • Cytokine results are referenced generally without specific findings
View raw extracted JSON
{
  "study_type": "in_vitro",
  "exposure": {
    "band": "microwave",
    "source": null,
    "frequency_mhz": 2450,
    "sar_wkg": null,
    "duration": null
  },
  "population": "THP-1 monocytes (stimulated with PMA and LPS; differentiated toward macrophage-like cells)",
  "sample_size": null,
  "outcomes": [
    "NFκB expression/activity in THP-1 monocytes under PMA+LPS stimulation",
    "Cytokine expression (mentioned generally)"
  ],
  "main_findings": "In PMA- and LPS-stimulated THP-1 monocytes, NFκB levels increased, and exposure to microwave radiation was reported to decrease NFκB expression. The authors conclude microwave radiation inhibited activity/functions of stimulated THP-1 monocytes.",
  "effect_direction": "benefit",
  "limitations": [
    "No exposure duration reported",
    "No SAR or dosimetry details reported (only frequency and power stated)",
    "Sample size not reported",
    "Outcome measurement methods not described in the abstract",
    "Cytokine results are referenced generally without specific findings"
  ],
  "evidence_strength": "very_low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "microwave radiation",
    "2450 MHz",
    "THP-1",
    "monocytes",
    "macrophage differentiation",
    "PMA",
    "LPS",
    "NFκB",
    "inflammation",
    "cytokines"
  ],
  "suggested_hubs": []
}
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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.4077/cjp.2011.amm067
PubMed: 23286450

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