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Ibuprofen effects on behavioral thermoregulation with microwave radiation in albino rats.

Perceptual and motor skills · 2001 · Mixed · Very low evidence

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MixedVery low evidencePaper 6379

In a within-subjects reversal design, ibuprofen dose (10–50 mg/kg, i.p.) was associated with significant differences in number of microwave heat reinforcers per hour and rate of responding, with both measures significantly higher during the first 2 hours of t…

Study snapshot

PublicationPerceptual and motor skills · 2001
Study typeanimal
Reported directionMixed
Evidence ratingVery low

Abstract

This study determined whether ibuprofen causes a disruptive behavior pattern similar to aspirin yet contrary to acetaminophen regarding thermoregulatory effects. 8 Sprague-Dawley rats (3 males and 5 females) were drawn from a population of rats which had been conditioned to press a lever for food reinforcement in an undergraduate course in operant conditioning. Animals were conditioned in a refrigerated Skinner Box on a fixed-interval 2-min. (FI-2 min.) schedule of microwave radiation (5 sec. of radiation per exposure occasion) in a repeated-measures reversal (within-subjects) design. The rats were injected intraperitoneally with doses of ibuprofen in amounts of 10-50 mg/kg or methyl-cellulose control vehicle of equal volume over 8-hr. daily sessions. A multivariate analysis of variance showed significant differences due to doses (mg/kg) of ibuprofen for number of microwave heat reinforcers per hour and rate of responding (ns) both measures of which were significantly higher during the first 2 hours of the session. Comparative differences in behavioral thermoregulation in humans reflect the likelihood of underlying biochemical mechanisms based on research by Murphy, Badia, Myers, Boecker, and Wright in 1994.

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal
Effect directionmixed
PopulationSprague-Dawley albino rats (3 males, 5 females)
Sample size8
Exposuremicrowave · 5 sec of radiation per exposure occasion; FI-2 min schedule; 8-hr daily sessions
Evidence strengthVery lowConfidence: 74% · Peer reviewed: yes

Main findings

In a within-subjects reversal design, ibuprofen dose (10–50 mg/kg, i.p.) was associated with significant differences in number of microwave heat reinforcers per hour and rate of responding, with both measures significantly higher during the first 2 hours of the session.

Outcomes measured

  • behavioral thermoregulation
  • number of microwave heat reinforcers per hour
  • rate of responding

Limitations

  • Very small sample size (n=8)
  • Microwave exposure frequency and dosimetry (e.g., SAR) not reported in abstract
  • Outcome measures are behavioral/operant metrics; generalizability to other endpoints not addressed in abstract
  • Details of statistical results (effect sizes, exact p-values) not provided in abstract
View raw extracted JSON
{
  "study_type": "animal",
  "exposure": {
    "band": "microwave",
    "source": null,
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": "5 sec of radiation per exposure occasion; FI-2 min schedule; 8-hr daily sessions"
  },
  "population": "Sprague-Dawley albino rats (3 males, 5 females)",
  "sample_size": 8,
  "outcomes": [
    "behavioral thermoregulation",
    "number of microwave heat reinforcers per hour",
    "rate of responding"
  ],
  "main_findings": "In a within-subjects reversal design, ibuprofen dose (10–50 mg/kg, i.p.) was associated with significant differences in number of microwave heat reinforcers per hour and rate of responding, with both measures significantly higher during the first 2 hours of the session.",
  "effect_direction": "mixed",
  "limitations": [
    "Very small sample size (n=8)",
    "Microwave exposure frequency and dosimetry (e.g., SAR) not reported in abstract",
    "Outcome measures are behavioral/operant metrics; generalizability to other endpoints not addressed in abstract",
    "Details of statistical results (effect sizes, exact p-values) not provided in abstract"
  ],
  "evidence_strength": "very_low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "microwave radiation",
    "behavioral thermoregulation",
    "ibuprofen",
    "operant conditioning",
    "rats",
    "Skinner box",
    "fixed-interval schedule"
  ],
  "suggested_hubs": []
}
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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.2466/pms.2001.92.2.391
PubMed: 11361298

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