[Changes in serum alkaline phosphatase activity during in vitro exposure to amplitude-modulated electromagnetic field of ultrahigh frequency (2375 MHz) in guinea pigs].

Biofizika · 2000 · Harm · Low evidence

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HarmLow evidencePaper 6372

In vitro exposure to pulse-modulated microwave radiation (carrier 2375 MHz; modulation pulse rate 10–390 Hz) altered alkaline phosphatase activity depending on modulation frequency and intensity. At 70 Hz modulation, alkaline phosphatase activity increased by…

Study snapshot

PublicationBiofizika · 2000

Study typeanimal

Reported directionHarm

Evidence ratingLow

Abstract

The activity of alkaline phosphatase by the action of pulse-modulated microwave radiation was studied. The carrier frequency of radiation was 2375 MHz, the range of modulation pulse rate was 10-390 Hz with the on-off time ratio 2, and the specific absorption rate was 8 and 0.8 microW/cm2. Time of exposure was 1 and 3 min under conditions of continuous temperature control. It was shown that the activity of alkaline phosphatase depends on both modulation frequency and intensity of superhigh-frequency electromagnetic radiation. At a frequency of 70 Hz, the activity of alkaline phosphatases increased 1.8-2.0 times.

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal

Effect directionharm

Populationguinea pigs (in vitro serum)

Sample sizeNot supplied

ExposureRF · 2375 MHz · 1 and 3 min

Evidence strengthLowConfidence: 74% · Peer reviewed: yes

Main findings

Outcomes measured

serum alkaline phosphatase activity

Limitations

In vitro study (serum enzyme activity) rather than whole-animal health outcomes
Sample size not reported in abstract
Exposure metric reported as microW/cm2; SAR in W/kg not provided
Short exposure durations (1 and 3 minutes)

View raw extracted JSON

{
  "study_type": "animal",
  "exposure": {
    "band": "RF",
    "source": null,
    "frequency_mhz": 2375,
    "sar_wkg": null,
    "duration": "1 and 3 min"
  },
  "population": "guinea pigs (in vitro serum)",
  "sample_size": null,
  "outcomes": [
    "serum alkaline phosphatase activity"
  ],
  "main_findings": "In vitro exposure to pulse-modulated microwave radiation (carrier 2375 MHz; modulation pulse rate 10–390 Hz) altered alkaline phosphatase activity depending on modulation frequency and intensity. At 70 Hz modulation, alkaline phosphatase activity increased by about 1.8–2.0 times.",
  "effect_direction": "harm",
  "limitations": [
    "In vitro study (serum enzyme activity) rather than whole-animal health outcomes",
    "Sample size not reported in abstract",
    "Exposure metric reported as microW/cm2; SAR in W/kg not provided",
    "Short exposure durations (1 and 3 minutes)"
  ],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "2375 MHz",
    "microwave",
    "RF",
    "pulse-modulated",
    "amplitude-modulated",
    "modulation frequency",
    "guinea pig",
    "in vitro",
    "alkaline phosphatase",
    "enzyme activity"
  ],
  "suggested_hubs": []
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: Not supplied
PubMed: 10732222

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