Inhibitory action of microwave radiation on gamma-glutamyl transpeptidase activity in liver of rats treated with hydrocortisone.

Folia histochemica et cytobiologica · 2000 · Mixed · Low evidence

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MixedLow evidencePaper 6364

In rats treated with hydrocortisone, microwave irradiation at 53.57 GHz (power density 10 mW/cm2 and 1 mW/cm2) was reported to block the inducible effect of hydrocortisone on liver GGT activity. The effect was described as dependent on the power density of mi…

Study snapshot

PublicationFolia histochemica et cytobiologica · 2000
Study typeanimal
Reported directionMixed
Evidence ratingLow

Abstract

The influence of microwave irradiation on the activity of gamma-glutamyl transpeptidase (GGT) induced by hydrocortisone (HC) in the liver of rats was investigated. Animals were subjected to microwave irradiation (frequency 53.57 GHz, power density 10 mW/cm2 and 1 mW/cm2) during and after hydrocortisone (HC) treatment (20 mg/kg for 60 days). The results indicate that microwave radiation may block an inducible effect of HC on GGT activity in the liver of rats. This effect depends on the power density of millimetre microwaves.

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal
Effect directionmixed
Populationrats
Sample sizeNot supplied
ExposuremmWave · 53570 MHz · during and after hydrocortisone treatment (20 mg/kg for 60 days)
Evidence strengthLowConfidence: 74% · Peer reviewed: yes

Main findings

In rats treated with hydrocortisone, microwave irradiation at 53.57 GHz (power density 10 mW/cm2 and 1 mW/cm2) was reported to block the inducible effect of hydrocortisone on liver GGT activity. The effect was described as dependent on the power density of millimetre microwaves.

Outcomes measured

  • gamma-glutamyl transpeptidase (GGT) activity in liver
  • hydrocortisone-induced GGT activity

Limitations

  • Sample size not reported in abstract
  • No sham/control details provided in abstract
  • Exposure duration and timing relative to irradiation not fully specified beyond 'during and after' treatment
  • No quantitative results or statistical details provided in abstract
View raw extracted JSON
{
  "study_type": "animal",
  "exposure": {
    "band": "mmWave",
    "source": null,
    "frequency_mhz": 53570,
    "sar_wkg": null,
    "duration": "during and after hydrocortisone treatment (20 mg/kg for 60 days)"
  },
  "population": "rats",
  "sample_size": null,
  "outcomes": [
    "gamma-glutamyl transpeptidase (GGT) activity in liver",
    "hydrocortisone-induced GGT activity"
  ],
  "main_findings": "In rats treated with hydrocortisone, microwave irradiation at 53.57 GHz (power density 10 mW/cm2 and 1 mW/cm2) was reported to block the inducible effect of hydrocortisone on liver GGT activity. The effect was described as dependent on the power density of millimetre microwaves.",
  "effect_direction": "mixed",
  "limitations": [
    "Sample size not reported in abstract",
    "No sham/control details provided in abstract",
    "Exposure duration and timing relative to irradiation not fully specified beyond 'during and after' treatment",
    "No quantitative results or statistical details provided in abstract"
  ],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "millimetre waves",
    "microwave irradiation",
    "53.57 GHz",
    "power density",
    "hydrocortisone",
    "gamma-glutamyl transpeptidase",
    "rat liver",
    "enzyme activity"
  ],
  "suggested_hubs": []
}
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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: Not supplied
PubMed: 11185725

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