The effect of microwave radiation on the stability and formation of gramicidin-A channels in lipid bilayer membranes.

Bioelectromagnetics · 1991 · Mixed · Low evidence

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MixedLow evidencePaper 6287

Microwave radiation did not affect single-channel conductance or channel lifetime beyond what was expected from purely thermal effects based on measured membrane-site temperature. However, the rate of channel formation decreased during exposure, opposite to w…

Study snapshot

PublicationBioelectromagnetics · 1991

Study typein_vitro

Reported directionMixed

Evidence ratingLow

Abstract

The effects of microwaves on the single-channel kinetics of gramicidin-A channels in lipid bilayer membranes were examined. Attempts were made to separate thermal and athermal effects by accurate measurements of temperature at the site of the membrane and by relating the measured parameters to their previously characterized temperature dependence. It was found that microwave radiation does not affect single-channel conductance or channel life time to a degree that is significantly different from that expected of a purely thermal effect. On the other hand, the rate of channel formation is decreased during exposure, which is opposite to that expected of a purely thermal effect. The mechanism of this effect is discussed in terms of the dimerization process of channel formation.

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typein_vitro

Effect directionmixed

PopulationNot supplied

Sample sizeNot supplied

Exposuremicrowave

Evidence strengthLowConfidence: 74% · Peer reviewed: yes

Main findings

Outcomes measured

single-channel conductance
channel lifetime
rate of channel formation
single-channel kinetics of gramicidin-A channels in lipid bilayer membranes

Limitations

Exposure parameters (e.g., frequency, SAR, duration) not reported in the provided abstract/metadata
In vitro lipid bilayer/gramicidin-A model; relevance to whole-organism health outcomes not addressed in the provided abstract

View raw extracted JSON

{
  "study_type": "in_vitro",
  "exposure": {
    "band": "microwave",
    "source": null,
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": null
  },
  "population": null,
  "sample_size": null,
  "outcomes": [
    "single-channel conductance",
    "channel lifetime",
    "rate of channel formation",
    "single-channel kinetics of gramicidin-A channels in lipid bilayer membranes"
  ],
  "main_findings": "Microwave radiation did not affect single-channel conductance or channel lifetime beyond what was expected from purely thermal effects based on measured membrane-site temperature. However, the rate of channel formation decreased during exposure, opposite to what would be expected from a purely thermal effect.",
  "effect_direction": "mixed",
  "limitations": [
    "Exposure parameters (e.g., frequency, SAR, duration) not reported in the provided abstract/metadata",
    "In vitro lipid bilayer/gramicidin-A model; relevance to whole-organism health outcomes not addressed in the provided abstract"
  ],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "microwave radiation",
    "gramicidin-A",
    "lipid bilayer membranes",
    "single-channel kinetics",
    "thermal effects",
    "athermal effects",
    "channel formation",
    "dimerization"
  ],
  "suggested_hubs": []
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1002/bem.2250120103
PubMed: 1707274

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