[Microwave radiation treatment of liver cancer: animal experiment and preliminary clinical application].

Zhonghua wai ke za zhi [Chinese journal of surgery] · 1989 · Benefit · Very low evidence

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BenefitVery low evidencePaper 6250

Study snapshot

PublicationZhonghua wai ke za zhi [Chinese journal of surgery] · 1989

Study typeother

Reported directionBenefit

Evidence ratingVery low

Abstract

Microwave radiation treatment of liver cancer in animals with microwave treatment apparatus (2450 MHz) in either a Single-antenna or 8-antenna (combined) radiator and its clinical use were reported. In laparotomy, the antenna was inserted into liver tissue or the hepatoma. The changes of liver pathology and ultra structure as well as the process of absorption and healing of radiated liver were investigated. The results showed that a large amount of air bubbles were formed in liver tissue and its small veins when the temperature was higher than 80 degrees C in the radiated center. These bubbles were drastically reduced in number when the temperature was controlled around 65 degrees C. The radiated liver was pathologically divided into three parts: necrosis area (the center of radiation), normal area (far from the center) and reactive area (between the necrosis and normal areas). The largest diameter of the coagulated area was about 5 cm. The coagulated tissue was completely absorbed 60 days after the operation. Seventeen cases of primary hepatoma and 8 cases of secondary liver cancers were treated with microwave radiation therapy with satisfactory results. The volume of bleeding during the operation was greatly reduced. No complication was found.

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Study typeother

Effect directionbenefit

PopulationAnimals with liver cancer; clinical cases with primary hepatoma and secondary liver cancers

Sample size25

Exposuremicrowave · 2450 MHz

Evidence strengthVery lowConfidence: 74% · Peer reviewed: yes

Main findings

In animal experiments using 2450 MHz microwave treatment, air bubbles formed in liver tissue and small veins when the radiated center temperature exceeded 80°C and were markedly reduced when temperature was controlled around 65°C. The radiated liver showed necrosis, reactive, and normal zones; the largest coagulated diameter was about 5 cm and coagulated tissue was completely absorbed by 60 days post-operation. Clinically, 17 primary hepatoma and 8 secondary liver cancer cases were treated with satisfactory results, with greatly reduced bleeding and no complications reported.

Outcomes measured

Liver pathology and ultrastructure changes after microwave radiation
Temperature-related formation of air bubbles in liver tissue/small veins
Size (diameter) of coagulated/necrotic area
Time to absorption/healing of coagulated tissue
Intraoperative bleeding volume
Complications
Clinical treatment results (satisfactory results)

Limitations

Study design details (e.g., controls, randomization) not described in abstract
Animal sample size not reported
Clinical outcomes are described qualitatively as 'satisfactory' without defined endpoints
Follow-up duration for clinical cases not stated

View raw extracted JSON

{
  "study_type": "other",
  "exposure": {
    "band": "microwave",
    "source": "medical microwave treatment apparatus",
    "frequency_mhz": 2450,
    "sar_wkg": null,
    "duration": null
  },
  "population": "Animals with liver cancer; clinical cases with primary hepatoma and secondary liver cancers",
  "sample_size": 25,
  "outcomes": [
    "Liver pathology and ultrastructure changes after microwave radiation",
    "Temperature-related formation of air bubbles in liver tissue/small veins",
    "Size (diameter) of coagulated/necrotic area",
    "Time to absorption/healing of coagulated tissue",
    "Intraoperative bleeding volume",
    "Complications",
    "Clinical treatment results (satisfactory results)"
  ],
  "main_findings": "In animal experiments using 2450 MHz microwave treatment, air bubbles formed in liver tissue and small veins when the radiated center temperature exceeded 80°C and were markedly reduced when temperature was controlled around 65°C. The radiated liver showed necrosis, reactive, and normal zones; the largest coagulated diameter was about 5 cm and coagulated tissue was completely absorbed by 60 days post-operation. Clinically, 17 primary hepatoma and 8 secondary liver cancer cases were treated with satisfactory results, with greatly reduced bleeding and no complications reported.",
  "effect_direction": "benefit",
  "limitations": [
    "Study design details (e.g., controls, randomization) not described in abstract",
    "Animal sample size not reported",
    "Clinical outcomes are described qualitatively as 'satisfactory' without defined endpoints",
    "Follow-up duration for clinical cases not stated"
  ],
  "evidence_strength": "very_low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "microwave radiation therapy",
    "2450 MHz",
    "liver cancer",
    "hepatoma",
    "thermal ablation",
    "pathology",
    "ultrastructure",
    "coagulation necrosis",
    "clinical application"
  ],
  "suggested_hubs": []
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: Not supplied
PubMed: 2560966

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