Microwave effect on camphor binding to rat olfactory epithelium.

Bioelectromagnetics · 1988 · Harm · Low evidence

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HarmLow evidencePaper 6233

Microwave radiation decreased specific camphor binding to a membrane fraction of rat olfactory epithelium, but not to a Triton X-100 extract of the fraction. The inhibition did not depend on modulation frequency (1–100 Hz) and was not a linear function of SAR…

Study snapshot

PublicationBioelectromagnetics · 1988
Study typeanimal
Reported directionHarm
Evidence ratingLow

Abstract

Microwave radiation decreased specific camphor binding to a membrane fraction of rat epithelium but not to a Triton X-100 extract of this fraction. Inhibition of the ligand binding did not depend on the modulation frequency of the microwave field in the region 1-100 Hz and was not a linear function of specific absorption rate (SAR). The decreased ligand binding was due to a shedding or release of the specific camphor-binding protein from the membrane into solution. It is highly probable that several other membrane proteins may be shed into solution during microwave exposure.

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal
Effect directionharm
PopulationRat olfactory epithelium (membrane fraction/extract)
Sample sizeNot supplied
Exposuremicrowave
Evidence strengthLowConfidence: 74% · Peer reviewed: yes

Main findings

Microwave radiation decreased specific camphor binding to a membrane fraction of rat olfactory epithelium, but not to a Triton X-100 extract of the fraction. The inhibition did not depend on modulation frequency (1–100 Hz) and was not a linear function of SAR. The decrease in binding was attributed to shedding/release of the specific camphor-binding protein from the membrane into solution.

Outcomes measured

  • Specific camphor binding to membrane fraction
  • Camphor binding to Triton X-100 extract
  • Shedding/release of camphor-binding protein from membrane into solution

Limitations

  • Sample size not reported in abstract
  • Microwave carrier frequency and exposure duration not reported in abstract
  • Outcome is a biochemical binding measure; broader physiological/health relevance not assessed in abstract
  • SAR-response described as non-linear but quantitative SAR levels not provided in abstract
View raw extracted JSON
{
  "study_type": "animal",
  "exposure": {
    "band": "microwave",
    "source": null,
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": null
  },
  "population": "Rat olfactory epithelium (membrane fraction/extract)",
  "sample_size": null,
  "outcomes": [
    "Specific camphor binding to membrane fraction",
    "Camphor binding to Triton X-100 extract",
    "Shedding/release of camphor-binding protein from membrane into solution"
  ],
  "main_findings": "Microwave radiation decreased specific camphor binding to a membrane fraction of rat olfactory epithelium, but not to a Triton X-100 extract of the fraction. The inhibition did not depend on modulation frequency (1–100 Hz) and was not a linear function of SAR. The decrease in binding was attributed to shedding/release of the specific camphor-binding protein from the membrane into solution.",
  "effect_direction": "harm",
  "limitations": [
    "Sample size not reported in abstract",
    "Microwave carrier frequency and exposure duration not reported in abstract",
    "Outcome is a biochemical binding measure; broader physiological/health relevance not assessed in abstract",
    "SAR-response described as non-linear but quantitative SAR levels not provided in abstract"
  ],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "microwave radiation",
    "rat",
    "olfactory epithelium",
    "camphor binding",
    "membrane proteins",
    "protein shedding",
    "modulation frequency",
    "SAR"
  ],
  "suggested_hubs": []
}
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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1002/bem.2250090404
PubMed: 3190762

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