Behavioral effects of chlorpromazine and diazepam combined with low-level microwaves.

Neurobehavioral toxicology · 1980 · No effect · Low evidence

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No effectLow evidencePaper 6033

Microwave exposure alone did not affect fixed interval performance in rats. Chlorpromazine decreased response rate and patterning, diazepam had dose-dependent effects on response rate and reduced patterning. Combining microwaves with either drug did not alter…

Study snapshot

PublicationNeurobehavioral toxicology · 1980

Study typeanimal

Reported directionNo effect

Evidence ratingLow

Abstract

Previous research findings on the interaction between drugs and microwave radiation were extended to chlorpromazine and to diazepam. The drugs were combined with a 1 mW/cm2 pulsed microwave field (2.8 GHz) and effects were measured on a fixed interval (FI 1) schedule of food reinforcement with rats. Dose-effect functions with and without sham irradiation were established for each drug. At effective doses chlorpromazine consistently decreased rate of responding and reduced with-interval response patterning. Low to moderate doses of diazepam produced little change or increases in response rate, and higher doses produced a decline in response rate. Response patterning within intervals was reduced by increasing doses of diazepam. The animals were exposed to the microwave field alone before test sessions combining the drugs with microwave radiation. Microwave exposure alone did not affect FI performance. Microwave radiation in combination with either drug did not produce any alterations in the dose-effect functions.

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal

Effect directionno_effect

Populationrats

Sample sizeNot supplied

Exposuremicrowave · 2800 MHz

Evidence strengthLowConfidence: 50% · Peer reviewed: yes

Main findings

Outcomes measured

rate of responding
response patterning on fixed interval schedule

Limitations

No sample size reported
Only one microwave power density tested
Only two drugs tested
Animal study limits direct human applicability

View raw extracted JSON

{
  "study_type": "animal",
  "exposure": {
    "band": "microwave",
    "source": null,
    "frequency_mhz": 2800,
    "sar_wkg": null,
    "duration": null
  },
  "population": "rats",
  "sample_size": null,
  "outcomes": [
    "rate of responding",
    "response patterning on fixed interval schedule"
  ],
  "main_findings": "Microwave exposure alone did not affect fixed interval performance in rats. Chlorpromazine decreased response rate and patterning, diazepam had dose-dependent effects on response rate and reduced patterning. Combining microwaves with either drug did not alter the drugs' dose-effect functions.",
  "effect_direction": "no_effect",
  "limitations": [
    "No sample size reported",
    "Only one microwave power density tested",
    "Only two drugs tested",
    "Animal study limits direct human applicability"
  ],
  "evidence_strength": "low",
  "confidence": 0.5,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "chlorpromazine",
    "diazepam",
    "microwave radiation",
    "behavioral effects",
    "rats",
    "fixed interval schedule"
  ],
  "suggested_hubs": []
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: Not supplied
PubMed: 7290309

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