Acute exposure to pulsed microwaves affects neither pentylenetetrazol seizures in the rat nor chlordiazepoxide protection against such seizures.

Radiation research · 1983 · No effect · Low evidence

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No effectLow evidencePaper 5938

Across three experiments, there was no consistent evidence that 2.70 GHz pulsed microwave radiation (up to 20 mW/cm2) affected pentylenetetrazol-induced seizures or altered the antiseizure efficacy of chlordiazepoxide. Microwave radiation counteracted the hyp…

Study snapshot

PublicationRadiation research · 1983
Study typeanimal
Reported directionNo effect
Evidence ratingLow

Abstract

Three experiments failed to provide consistent evidence for an effect of 2.70 GHz pulsed microwave radiation up to 20 mW/cm2 on pentylenetetrazol-induced seizures or on the efficacy of chlordiazepoxide for counteracting such seizures. Microwave radiation counteracted the hypothermic effects of chlordiazepoxide without altering its antiseizure efficacy. This underscores the dissociation between thermal and pharmacological effects of microwaves.

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal
Effect directionno_effect
PopulationRat
Sample sizeNot supplied
Exposuremicrowave · 2700 MHz
Evidence strengthLowConfidence: 74% · Peer reviewed: yes

Main findings

Across three experiments, there was no consistent evidence that 2.70 GHz pulsed microwave radiation (up to 20 mW/cm2) affected pentylenetetrazol-induced seizures or altered the antiseizure efficacy of chlordiazepoxide. Microwave radiation counteracted the hypothermic effects of chlordiazepoxide without changing its antiseizure efficacy.

Outcomes measured

  • Pentylenetetrazol-induced seizures
  • Efficacy of chlordiazepoxide protection against seizures
  • Hypothermic effects of chlordiazepoxide (body temperature/thermal effect)

Limitations

  • Sample size not reported in the abstract
  • Exposure duration not reported in the abstract
  • Results described as lacking consistent evidence across experiments (details not provided)
View raw extracted JSON
{
  "study_type": "animal",
  "exposure": {
    "band": "microwave",
    "source": null,
    "frequency_mhz": 2700,
    "sar_wkg": null,
    "duration": null
  },
  "population": "Rat",
  "sample_size": null,
  "outcomes": [
    "Pentylenetetrazol-induced seizures",
    "Efficacy of chlordiazepoxide protection against seizures",
    "Hypothermic effects of chlordiazepoxide (body temperature/thermal effect)"
  ],
  "main_findings": "Across three experiments, there was no consistent evidence that 2.70 GHz pulsed microwave radiation (up to 20 mW/cm2) affected pentylenetetrazol-induced seizures or altered the antiseizure efficacy of chlordiazepoxide. Microwave radiation counteracted the hypothermic effects of chlordiazepoxide without changing its antiseizure efficacy.",
  "effect_direction": "no_effect",
  "limitations": [
    "Sample size not reported in the abstract",
    "Exposure duration not reported in the abstract",
    "Results described as lacking consistent evidence across experiments (details not provided)"
  ],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "pulsed microwaves",
    "2.70 GHz",
    "2700 MHz",
    "rat",
    "pentylenetetrazol",
    "seizures",
    "chlordiazepoxide",
    "hypothermia",
    "thermal effects"
  ],
  "suggested_hubs": []
}
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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: Not supplied
PubMed: 6228950

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