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Microwave radiation-induced calcium ion efflux from human neuroblastoma cells in culture.

Bioelectromagnetics · 1984 · Mixed · Low evidence

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MixedLow evidencePaper 5931

Exposure to 915 MHz microwave radiation at SAR values of 0.05 and 1 mW/g caused a significant increase in calcium ion efflux from human neuroblastoma cells compared to controls. The increase at 0.05 mW/g required 16 Hz amplitude modulation, while the increase…

Study snapshot

PublicationBioelectromagnetics · 1984
Study typein_vitro
Reported directionMixed
Evidence ratingLow

Abstract

Monolayer cultures of human neuroblastoma cells were exposed to 915-MHz radiation, with or without sinusoidal amplitude modulation (80%) at 16 Hz, at specific absorption rates (SAR) for the culture medium and cells of 0.00, 0.01, 0.05, 0.075, 0.1, 0.5, 0.75, 1.0, 1.5, 2, or 5 mW/g. A significant increase in the efflux of calcium ions (45Ca2+) as compared to unexposed control cultures occurred at two SAR values: 0.05 and 1 mW/g. Increased efflux at 0.05 mW/g was dependent on the presence of amplitude modulation at 16 Hz but at the higher value it was not. These results indicate that human neuroblastoma cells are sensitive to extremely low levels of microwave radiation at certain narrow ranges of SAR.

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typein_vitro
Effect directionmixed
Populationhuman neuroblastoma cells in culture
Sample sizeNot supplied
Exposuremicrowave · 915 MHz · 0.05 W/kg
Evidence strengthLowConfidence: 50% · Peer reviewed: yes

Main findings

Exposure to 915 MHz microwave radiation at SAR values of 0.05 and 1 mW/g caused a significant increase in calcium ion efflux from human neuroblastoma cells compared to controls. The increase at 0.05 mW/g required 16 Hz amplitude modulation, while the increase at 1 mW/g did not.

Outcomes measured

  • calcium ion (45Ca2+) efflux

Limitations

  • in vitro study, limiting direct extrapolation to humans
  • only specific SAR values showed effects, indicating narrow sensitivity range
  • no information on exposure duration or long-term effects
View raw extracted JSON
{
  "study_type": "in_vitro",
  "exposure": {
    "band": "microwave",
    "source": null,
    "frequency_mhz": 915,
    "sar_wkg": 0.05,
    "duration": null
  },
  "population": "human neuroblastoma cells in culture",
  "sample_size": null,
  "outcomes": [
    "calcium ion (45Ca2+) efflux"
  ],
  "main_findings": "Exposure to 915 MHz microwave radiation at SAR values of 0.05 and 1 mW/g caused a significant increase in calcium ion efflux from human neuroblastoma cells compared to controls. The increase at 0.05 mW/g required 16 Hz amplitude modulation, while the increase at 1 mW/g did not.",
  "effect_direction": "mixed",
  "limitations": [
    "in vitro study, limiting direct extrapolation to humans",
    "only specific SAR values showed effects, indicating narrow sensitivity range",
    "no information on exposure duration or long-term effects"
  ],
  "evidence_strength": "low",
  "confidence": 0.5,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "microwave radiation",
    "calcium ion efflux",
    "human neuroblastoma cells",
    "specific absorption rate",
    "amplitude modulation"
  ],
  "suggested_hubs": []
}
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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1002/bem.2250050108
PubMed: 6712751

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