Effect of rmEGF combined with ELF-EMF on promoting wound healing in rats.

Technology and health care : official journal of the European Society for Engineering and Medicine · 2024 · Benefit · Low evidence

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BenefitLow evidencePaper 5856

In rats, the rmEGF+ELF-EMF group had a better wound healing rate than the other groups. HE staining indicated improved early inflammatory cell infiltration, fibroblast arrangement, and increased new capillaries in the rmEGF+ELF-EMF group compared with other g…

Study snapshot

PublicationTechnology and health care : official journal of the European Society for Engineering and Medicine · 2024

Study typeanimal

Reported directionBenefit

Evidence ratingLow

Abstract

BACKGROUND: The process of wound healing is complex, and expediting it remains a challenge. The advantages of extremely low frequency electric and magnetic fields (ELF-EMF) are its non-invasive treatment, promotes healing and promotes myogenesis of C2C12 cells. Epidermal growth factor (EGF) is known to play a vital role in promoting wound healing, so a combination of ELF-EMF and EGF can have far-reaching significance. OBJECTIVE: To study the effect of recombinant murine epidermal growth factor (rmEGF) combined with ELF-EMF on wound healing. METHODS: Thirty-six rats were randomly divided into three groups: normal control group, EGF group, and ELF-EMF+EGF group, and a 20 mm × 20 mm dorsal wound was made. The wound healing rate of rats was calculated on the 3rd, 7th, 11th and 15th day. HE staining was used to observe the micro-morphological changes during the wound healing process. RESULTS: The wound healing rate of EGF+ELF-EMF group was better than other groups. On the 15th day of wound healing, the wounds of each group were completely healed. On the 3rd, 7th, 11th and 15th day of HE staining, the early inflammatory cell infiltration, the arrangement of fibroblasts and the number of new capillaries in the wounds of EGF+ELF-EMF group were better than those of the other groups. CONCLUSIONS: rmEGF combined with ELF-EMF significantly promotes wound healing in SD rats.

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal

Effect directionbenefit

PopulationSD rats with a 20 mm × 20 mm dorsal wound

Sample size36

ExposureELF

Evidence strengthLowConfidence: 74% · Peer reviewed: yes

Main findings

Outcomes measured

Wound healing rate (days 3, 7, 11, 15)
Histological/micromorphological changes by HE staining (inflammatory cell infiltration, fibroblast arrangement, new capillaries)

Limitations

No ELF-EMF-only group described in the abstract
ELF-EMF exposure parameters (e.g., frequency, field strength, exposure schedule) not reported in the abstract
Blinding and randomization details beyond group assignment not reported in the abstract
Short follow-up (up to 15 days) and animal model limits generalizability to humans

View raw extracted JSON

{
  "study_type": "animal",
  "exposure": {
    "band": "ELF",
    "source": "other",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": null
  },
  "population": "SD rats with a 20 mm × 20 mm dorsal wound",
  "sample_size": 36,
  "outcomes": [
    "Wound healing rate (days 3, 7, 11, 15)",
    "Histological/micromorphological changes by HE staining (inflammatory cell infiltration, fibroblast arrangement, new capillaries)"
  ],
  "main_findings": "In rats, the rmEGF+ELF-EMF group had a better wound healing rate than the other groups. HE staining indicated improved early inflammatory cell infiltration, fibroblast arrangement, and increased new capillaries in the rmEGF+ELF-EMF group compared with other groups; by day 15, wounds in all groups were completely healed.",
  "effect_direction": "benefit",
  "limitations": [
    "No ELF-EMF-only group described in the abstract",
    "ELF-EMF exposure parameters (e.g., frequency, field strength, exposure schedule) not reported in the abstract",
    "Blinding and randomization details beyond group assignment not reported in the abstract",
    "Short follow-up (up to 15 days) and animal model limits generalizability to humans"
  ],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "ELF-EMF",
    "extremely low frequency",
    "epidermal growth factor",
    "rmEGF",
    "wound healing",
    "rats",
    "HE staining",
    "angiogenesis",
    "fibroblasts"
  ],
  "suggested_hubs": []
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.3233/thc-248028
PubMed: 38669498

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