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Low-frequency electromagnetic fields promote hair follicles regeneration by injection a mixture of epidermal stem cells and dermal papilla cells.

Electromagnetic biology and medicine · 2020 · Benefit · Low evidence

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BenefitLow evidencePaper 5632

Nude mice receiving ESC+DP cell mixtures and exposed to low-frequency EMF showed higher density of erupted hair follicles after 14 days (epidermal implantation) compared with controls. After 7 days (corium implantation), H&E staining indicated more epidermal …

Study snapshot

PublicationElectromagnetic biology and medicine · 2020
Study typeanimal
Reported directionBenefit
Evidence ratingLow

Abstract

The bioeffects of low-frequency electromagnetic fields (EMF) on a bio-engineered hair follicle generation had not been fully elucidated. This present study was designed to evaluat the therapeutically effective of low frequency EMF on hair follicles regeneration. In this experiment, epidermal stem cells (ESCs) and dermal papilla (DP) cells were isolated and culture-expanded. Then the mixture containing of ESCs and DP cells was implanted into the epidermal layer or corium layer of nude mice. Those mice were  divided at random into the control group and EMF group, 7 days or 14 days later, the skin specimens were harvested to assess for hair regeneration or a bio-engineered skin formation using H&E staining. After injection of the mixture into the epidermal layer of nude mice for 14 days, H&E staining showed that the new hair formed the correct structure comprising hair matrix, hair shaft, and inner root sheath, outer root sheath, and DP. Comparing to the control, the hair follicles erupted at a higher density in the EMF group. When the mixture was implanted into the corium layer for 7 days, comparing with the characteristics of new hair follicles in the control group, H&E staining also showed the mixture induced to form 4 ~ 6 epidermal layers with a higher density of hair follicle like-structures in the bioengineered epithelial layers after EMF exposure. Our results suggested that the injection of a mixture of ESCs and DP cells in combination with EMF exposure facilitated the induction of hair follicle regeneration and a bioengineered skin formation with hair follicle-like structures.

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal
Effect directionbenefit
PopulationNude mice implanted with a mixture of epidermal stem cells (ESCs) and dermal papilla (DP) cells
Sample sizeNot supplied
Exposurelow-frequency · 7 days or 14 days
Evidence strengthLowConfidence: 74% · Peer reviewed: yes

Main findings

Nude mice receiving ESC+DP cell mixtures and exposed to low-frequency EMF showed higher density of erupted hair follicles after 14 days (epidermal implantation) compared with controls. After 7 days (corium implantation), H&E staining indicated more epidermal layers and higher density of hair follicle-like structures in EMF-exposed mice versus controls.

Outcomes measured

  • Hair follicle regeneration
  • Hair follicle density
  • Bio-engineered skin formation
  • Formation of hair follicle-like structures
  • Histology (H&E staining)

Limitations

  • EMF exposure parameters (e.g., frequency, intensity) not reported in the abstract
  • Sample size not reported in the abstract
  • Outcome assessment appears histological; no functional/long-term outcomes described in the abstract
View raw extracted JSON
{
  "study_type": "animal",
  "exposure": {
    "band": "low-frequency",
    "source": null,
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": "7 days or 14 days"
  },
  "population": "Nude mice implanted with a mixture of epidermal stem cells (ESCs) and dermal papilla (DP) cells",
  "sample_size": null,
  "outcomes": [
    "Hair follicle regeneration",
    "Hair follicle density",
    "Bio-engineered skin formation",
    "Formation of hair follicle-like structures",
    "Histology (H&E staining)"
  ],
  "main_findings": "Nude mice receiving ESC+DP cell mixtures and exposed to low-frequency EMF showed higher density of erupted hair follicles after 14 days (epidermal implantation) compared with controls. After 7 days (corium implantation), H&E staining indicated more epidermal layers and higher density of hair follicle-like structures in EMF-exposed mice versus controls.",
  "effect_direction": "benefit",
  "limitations": [
    "EMF exposure parameters (e.g., frequency, intensity) not reported in the abstract",
    "Sample size not reported in the abstract",
    "Outcome assessment appears histological; no functional/long-term outcomes described in the abstract"
  ],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "low-frequency electromagnetic fields",
    "EMF",
    "hair follicle regeneration",
    "epidermal stem cells",
    "dermal papilla cells",
    "nude mice",
    "bioengineered skin",
    "H&E staining"
  ],
  "suggested_hubs": []
}
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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1080/15368378.2020.1793165
PubMed: 32727226

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