RF Safe

Exposure to mobile phone radiations at 2350 MHz incites cyto- and genotoxic effects in root meristems of .

Journal of environmental health science & engineering · 2019 · Mixed · Low evidence

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MixedLow evidencePaper 5578

Compared with control, mitotic index and chromosomal aberrations increased significantly after 4 h and after ≥2 h exposure, respectively. Phase index showed no specific changes. Comet assay showed significant changes in %HDNA (2 h) and %TDNA (4 h), while TM a…

Study snapshot

PublicationJournal of environmental health science & engineering · 2019
Study typeanimal
Reported directionMixed
Evidence ratingLow

Abstract

BACKGROUND: The exponential increase of electromagnetic field radiations (EMF-r) in the natural environment has raked up the controversies regarding their biological effects. Concern regarding the putative capacity of EMF-r to affect living beings has been growing due to the ongoing elevation in the use of high frequency EMF-r in communication systems, e.g. Mobile phones. METHODS: In the present study, we tried to examine the cyto- and genotoxic potential of mobile phone EMF-r at 2350 MHz using onions ( L.). Fresh adventitious onion roots were exposed to continuous EMF-r at 2350 MHz for different time periods (1 h, 2 h and 4 h). The evaluation of cytotoxicity was done in terms of mitotic index (MI), phase index and chromosomal aberrations. Genotoxicity was investigated employing comet assay in terms of changes in % HDNA (head DNA) and % TDNA (tail DNA), TM (tail moment) and OTM (olive tail moment). Data were analyzed using one-way ANOVA and mean values were separated using post hoc Tukey's test. RESULTS: The results manifested a significant increase of MI and chromosomal aberrations (%) upon 4 h, and ≥ 2 h of exposure, respectively, as compared to the control. No specific changes in phase index in response to EMF-r exposure were observed. The % HDNA and % TDNA values exhibited significant changes in contrast to that of control upon 2 h and 4 h of exposure, respectively. However, TM and OTM did not change significantly. CONCLUSIONS: Our results infer that continuous exposures of radiofrequency EMF-r (2350 MHz) for long durations have a potential of inciting cyto- and genotoxic effects in onion root meristems.

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal
Effect directionmixed
PopulationOnion (Allium cepa L.) root meristems (fresh adventitious onion roots)
Sample sizeNot supplied
ExposureRF · 2350 MHz · Continuous exposure for 1 h, 2 h, and 4 h
Evidence strengthLowConfidence: 74% · Peer reviewed: yes

Main findings

Compared with control, mitotic index and chromosomal aberrations increased significantly after 4 h and after ≥2 h exposure, respectively. Phase index showed no specific changes. Comet assay showed significant changes in %HDNA (2 h) and %TDNA (4 h), while TM and OTM did not change significantly.

Outcomes measured

  • Mitotic index (MI)
  • Phase index
  • Chromosomal aberrations
  • Comet assay endpoints: % head DNA (%HDNA), % tail DNA (%TDNA), tail moment (TM), olive tail moment (OTM)

Limitations

  • Sample size not reported in abstract
  • Specific exposure metrics beyond frequency/duration (e.g., SAR, power density, distance) not reported in abstract
  • Only a plant model (onion root meristems); generalizability to humans not addressed in abstract
  • Some genotoxicity endpoints (TM, OTM) were not significantly changed
View raw extracted JSON
{
  "study_type": "animal",
  "exposure": {
    "band": "RF",
    "source": "mobile phone",
    "frequency_mhz": 2350,
    "sar_wkg": null,
    "duration": "Continuous exposure for 1 h, 2 h, and 4 h"
  },
  "population": "Onion (Allium cepa L.) root meristems (fresh adventitious onion roots)",
  "sample_size": null,
  "outcomes": [
    "Mitotic index (MI)",
    "Phase index",
    "Chromosomal aberrations",
    "Comet assay endpoints: % head DNA (%HDNA), % tail DNA (%TDNA), tail moment (TM), olive tail moment (OTM)"
  ],
  "main_findings": "Compared with control, mitotic index and chromosomal aberrations increased significantly after 4 h and after ≥2 h exposure, respectively. Phase index showed no specific changes. Comet assay showed significant changes in %HDNA (2 h) and %TDNA (4 h), while TM and OTM did not change significantly.",
  "effect_direction": "mixed",
  "limitations": [
    "Sample size not reported in abstract",
    "Specific exposure metrics beyond frequency/duration (e.g., SAR, power density, distance) not reported in abstract",
    "Only a plant model (onion root meristems); generalizability to humans not addressed in abstract",
    "Some genotoxicity endpoints (TM, OTM) were not significantly changed"
  ],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "radiofrequency",
    "EMF-r",
    "mobile phone radiation",
    "2350 MHz",
    "onion",
    "Allium cepa",
    "root meristems",
    "cytotoxicity",
    "genotoxicity",
    "chromosomal aberrations",
    "comet assay"
  ],
  "suggested_hubs": []
}
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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1007/s40201-018-00330-1
PubMed: 31297205

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