Effects of 60 Hz extremely low frequency magnetic fields (EMF) on radiation- and chemical-induced mutagenesis in mammalian cells.

Carcinogenesis · 2000 · No effect · Low evidence

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No effectLow evidencePaper 5347

A(L) cells exposed to a 100 microT, 60 Hz alternating magnetic field for up to 7 days showed no cytotoxicity and no increase in mutagenesis. Concurrent EMF exposure did not increase cytotoxicity or CD59- mutant induction from graded doses of gamma-radiation o…

Study snapshot

PublicationCarcinogenesis · 2000

Study typein_vitro

Reported directionNo effect

Evidence ratingLow

Abstract

There is considerable uncertainty of the potential biological effects of extremely low frequency magnetic fields (ELF-MF or EMF) because of mixed results in epidemiological and laboratory studies. In the present study, exponentially growing human-hamster hybrid A(L) cells were treated with a 100 microT alternating EMF powered at 60 Hz for either 24 h or 7 days. Exposure to EMF was conducted either alone or in combination with graded doses of a physical or chemical carcinogen. gamma-radiation was chosen as a form of ionizing radiation while N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) was chosen as a form of chemical contaminant. Exposure of A(L) cells to EMF alone for a period up to 7 days was non-cytotoxic and non-mutagenic. Concurrent EMF treatment did not increase either the cytotoxicity or induction of CD59- mutants by graded doses of gamma-rays or MNNG in A(L) cells. This study shows conclusively that short-term or long-term exposure to EMF alone neither affects the survival of A(L) cells nor increases the mutagenic potency of other environmental carcinogens.

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typein_vitro

Effect directionno_effect

PopulationExponentially growing human-hamster hybrid A(L) cells

Sample sizeNot supplied

ExposureELF · 0.06 MHz · 24 h or 7 days

Evidence strengthLowConfidence: 78% · Peer reviewed: yes

Main findings

Outcomes measured

Cytotoxicity/survival
Mutagenesis (CD59- mutants)
Mutagenic potency of gamma-radiation
Mutagenic potency of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)

View raw extracted JSON

{
  "study_type": "in_vitro",
  "exposure": {
    "band": "ELF",
    "source": null,
    "frequency_mhz": 0.06,
    "sar_wkg": null,
    "duration": "24 h or 7 days"
  },
  "population": "Exponentially growing human-hamster hybrid A(L) cells",
  "sample_size": null,
  "outcomes": [
    "Cytotoxicity/survival",
    "Mutagenesis (CD59- mutants)",
    "Mutagenic potency of gamma-radiation",
    "Mutagenic potency of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)"
  ],
  "main_findings": "A(L) cells exposed to a 100 microT, 60 Hz alternating magnetic field for up to 7 days showed no cytotoxicity and no increase in mutagenesis. Concurrent EMF exposure did not increase cytotoxicity or CD59- mutant induction from graded doses of gamma-radiation or MNNG.",
  "effect_direction": "no_effect",
  "limitations": [],
  "evidence_strength": "low",
  "confidence": 0.78,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "extremely low frequency magnetic fields",
    "ELF-MF",
    "60 Hz",
    "100 microT",
    "in vitro",
    "A(L) cells",
    "gamma-radiation",
    "MNNG",
    "mutagenesis",
    "cytotoxicity",
    "CD59 mutants"
  ],
  "suggested_hubs": [
    {
      "slug": "who-icnirp",
      "weight": 0.25,
      "reason": "Study addresses biological effects of ELF magnetic fields relevant to health risk assessment discussions."
    }
  ]
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: Not supplied
PubMed: 10837013

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