[Modulation by ultralow intensity electromagnetic fields on pharmacologic effects of psychotropic drugs].

Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova · 2001 · Mixed · Very low evidence

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MixedVery low evidencePaper 5316

Study snapshot

PublicationZhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova · 2001

Study typeanimal

Reported directionMixed

Evidence ratingVery low

Abstract

The ultralow-intensity electromagnetic fields (EMF, frequency of 4200, modulated by a quasistochastic signal in the range of 20-20,000 Hz, power density of 15 microW/cm2, specific body absorption rate up to 4.5 mJ/kg) potentiated the hypnogenic effect of hexenal. The exposure to the EMF shortened the time of falling asleep induced by this drug and increased sleep duration in rats. The exposure to the EMF also potentiated haloperidol catalepsy: it decreased the drug threshold dose and increased the catalepsy duration. The EMF influence on the haloperidol effects was of a prolonged character: it was manifest in a selected suppression of the emotional excitation in the open-field test within 24 hours after the exposure.

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal

Effect directionmixed

PopulationRats

Sample sizeNot supplied

Exposure4200 MHz

Evidence strengthVery lowConfidence: 74% · Peer reviewed: yes

Main findings

Ultralow-intensity EMF exposure (4200 MHz, quasistochastic modulation 20–20,000 Hz; power density 15 microW/cm2; specific body absorption rate up to 4.5 mJ/kg) potentiated hexenal-induced sleep in rats by shortening time to fall asleep and increasing sleep duration. The same EMF exposure potentiated haloperidol catalepsy by decreasing the threshold dose and increasing catalepsy duration, with a prolonged effect reflected as suppression of emotional excitation in the open-field test within 24 hours after exposure.

Outcomes measured

Hypnogenic effect of hexenal (sleep onset time, sleep duration)
Haloperidol-induced catalepsy (threshold dose, duration)
Emotional excitation in open-field test (within 24 hours after exposure)

Limitations

Sample size not reported in abstract
Exposure duration not reported in abstract
Study design details (randomization/blinding/control conditions) not reported in abstract
Outcomes limited to animal model and specific pharmacologic endpoints

View raw extracted JSON

{
  "study_type": "animal",
  "exposure": {
    "band": null,
    "source": null,
    "frequency_mhz": 4200,
    "sar_wkg": null,
    "duration": null
  },
  "population": "Rats",
  "sample_size": null,
  "outcomes": [
    "Hypnogenic effect of hexenal (sleep onset time, sleep duration)",
    "Haloperidol-induced catalepsy (threshold dose, duration)",
    "Emotional excitation in open-field test (within 24 hours after exposure)"
  ],
  "main_findings": "Ultralow-intensity EMF exposure (4200 MHz, quasistochastic modulation 20–20,000 Hz; power density 15 microW/cm2; specific body absorption rate up to 4.5 mJ/kg) potentiated hexenal-induced sleep in rats by shortening time to fall asleep and increasing sleep duration. The same EMF exposure potentiated haloperidol catalepsy by decreasing the threshold dose and increasing catalepsy duration, with a prolonged effect reflected as suppression of emotional excitation in the open-field test within 24 hours after exposure.",
  "effect_direction": "mixed",
  "limitations": [
    "Sample size not reported in abstract",
    "Exposure duration not reported in abstract",
    "Study design details (randomization/blinding/control conditions) not reported in abstract",
    "Outcomes limited to animal model and specific pharmacologic endpoints"
  ],
  "evidence_strength": "very_low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "ultralow-intensity electromagnetic fields",
    "4200 MHz",
    "quasistochastic modulation",
    "20-20000 Hz",
    "power density 15 microW/cm2",
    "specific body absorption rate",
    "rats",
    "hexenal",
    "sleep",
    "haloperidol",
    "catalepsy",
    "open-field test"
  ],
  "suggested_hubs": []
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: Not supplied
PubMed: 11550647

Read the original paper →

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