RF Safe

Apoptosis induced by ultraviolet radiation is enhanced by amplitude modulated radiofrequency radiation in mutant yeast cells.

Bioelectromagnetics · 2004 · Mixed · Low evidence

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MixedLow evidencePaper 5239

Amplitude-modulated RF exposure (217 pulses/s) significantly enhanced UV-induced apoptosis in cdc48-mutant yeast cells under elevated temperature conditions. No effect was observed with unmodulated RF fields at identical time-average SARs (0.4 or 3.0 W/kg).

Study snapshot

PublicationBioelectromagnetics · 2004
Study typeanimal
Reported directionMixed
Evidence ratingLow

Abstract

The aim of this study was to investigate whether radiofrequency (RF) electromagnetic field (EMF) exposure affects cell death processes of yeast cells. Saccharomyces cerevisiae yeast cells of the strains KFy417 (wild-type) and KFy437 (cdc48-mutant) were exposed to 900 or 872 MHz RF fields, with or without exposure to ultraviolet (UV) radiation, and incubated simultaneously with elevated temperature (+37 degrees C) to induce apoptosis in the cdc48-mutated strain. The RF exposure was carried out in a special waveguide exposure chamber where the temperature of the cell cultures can be precisely controlled. Apoptosis was analyzed using the annexin V-FITC method utilizing flow cytometry. Amplitude modulated (217 pulses per second) RF exposure significantly enhanced UV induced apoptosis in cdc48-mutated cells, but no effect was observed in cells exposed to unmodulated fields at identical time-average specfic absorption rates (SAR, 0.4 or 3.0 W/kg). The findings suggest that amplitude modulated RF fields, together with known damaging agents, can affect the cell death process in mutated yeast cells. Bioelectromagnetics 25:127-133, 2004.

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal
Effect directionmixed
PopulationSaccharomyces cerevisiae yeast cells (wild-type KFy417 and cdc48-mutant KFy437 strains)
Sample sizeNot supplied
ExposureRF · 900 MHz
Evidence strengthLowConfidence: 74% · Peer reviewed: yes

Main findings

Amplitude-modulated RF exposure (217 pulses/s) significantly enhanced UV-induced apoptosis in cdc48-mutant yeast cells under elevated temperature conditions. No effect was observed with unmodulated RF fields at identical time-average SARs (0.4 or 3.0 W/kg).

Outcomes measured

  • Apoptosis (annexin V-FITC flow cytometry)
  • UV-induced apoptosis modulation by RF exposure

Limitations

  • Sample size not reported in abstract
  • Exposure duration not reported in abstract
  • Effects described for mutant yeast cells and in combination with UV and elevated temperature; generalizability to other models is unclear from abstract
View raw extracted JSON
{
  "study_type": "animal",
  "exposure": {
    "band": "RF",
    "source": null,
    "frequency_mhz": 900,
    "sar_wkg": null,
    "duration": null
  },
  "population": "Saccharomyces cerevisiae yeast cells (wild-type KFy417 and cdc48-mutant KFy437 strains)",
  "sample_size": null,
  "outcomes": [
    "Apoptosis (annexin V-FITC flow cytometry)",
    "UV-induced apoptosis modulation by RF exposure"
  ],
  "main_findings": "Amplitude-modulated RF exposure (217 pulses/s) significantly enhanced UV-induced apoptosis in cdc48-mutant yeast cells under elevated temperature conditions. No effect was observed with unmodulated RF fields at identical time-average SARs (0.4 or 3.0 W/kg).",
  "effect_direction": "mixed",
  "limitations": [
    "Sample size not reported in abstract",
    "Exposure duration not reported in abstract",
    "Effects described for mutant yeast cells and in combination with UV and elevated temperature; generalizability to other models is unclear from abstract"
  ],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "radiofrequency",
    "RF",
    "872 MHz",
    "900 MHz",
    "amplitude modulation",
    "217 pulses per second",
    "SAR",
    "0.4 W/kg",
    "3.0 W/kg",
    "ultraviolet radiation",
    "UV",
    "apoptosis",
    "annexin V-FITC",
    "flow cytometry",
    "Saccharomyces cerevisiae",
    "cdc48 mutant",
    "waveguide exposure chamber"
  ],
  "suggested_hubs": []
}
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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1002/bem.10167
PubMed: 14735563

Read the original paper →

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