[Change in pain reaction by combined action of nitric oxide modulators and low intensity electromagnetic field].

Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) · 2005 · Mixed · Low evidence

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MixedLow evidencePaper 5158

In mice with formalin-induced tonic pain, low-intensity electromagnetic field (EMF) exposure altered the effects of nitric oxide (NO) modulators on painful behavioural reaction. EMF exposure completely eliminated the effects of L-NAME and sodium nitrite (0.5 …

Study snapshot

PublicationFiziolohichnyi zhurnal (Kiev, Ukraine : 1994) · 2005

Study typeanimal

Reported directionMixed

Evidence ratingLow

Abstract

In experiments on mice with the tonic pain caused by introduced of 5% of formalin in hindpaw, are quantitatively measure changes of painful behavioural reaction (PBR) values under action low intensity electromagnetic field (EMF) and substances that modulate activity of NO-synthase system, and at both of these action also. Such substances were used: in quality inhibitor NO-synthase--Nw-nitro-L-arginin (L-NAME), donors NO--sodium nitroprusside (SNP) and sodium nitrite (SN). Influence of the EMF completely eliminated effect of the L-NAME and SN in concentration of 0.5 mM/l, and also SNP in concentration 5 mcM/l on the painful reaction. The assumption that neurogenetics and NO- ergic mechanisms are basis of the systems analgesic effects of the low intensity electromagnetic fields. Mechanisms of modulation of painful behavioural reaction and other behavioural displays of animals under condition EMF and NO are discussed.

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal

Effect directionmixed

PopulationMice

Sample sizeNot supplied

ExposureNot supplied

Evidence strengthLowConfidence: 66% · Peer reviewed: yes

Main findings

Outcomes measured

Painful behavioural reaction (PBR) in formalin-induced tonic pain model

Limitations

No EMF exposure parameters reported (e.g., frequency, intensity, duration).
Sample size not reported.
Outcome reporting is qualitative/summary; direction and magnitude of EMF effect on pain itself is not clearly quantified in the abstract.
Potential mechanistic statements are speculative and not directly demonstrated in the abstract.

View raw extracted JSON

{
  "study_type": "animal",
  "exposure": {
    "band": null,
    "source": null,
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": null
  },
  "population": "Mice",
  "sample_size": null,
  "outcomes": [
    "Painful behavioural reaction (PBR) in formalin-induced tonic pain model"
  ],
  "main_findings": "In mice with formalin-induced tonic pain, low-intensity electromagnetic field (EMF) exposure altered the effects of nitric oxide (NO) modulators on painful behavioural reaction. EMF exposure completely eliminated the effects of L-NAME and sodium nitrite (0.5 mM/L) and sodium nitroprusside (5 µM/L) on the pain reaction.",
  "effect_direction": "mixed",
  "limitations": [
    "No EMF exposure parameters reported (e.g., frequency, intensity, duration).",
    "Sample size not reported.",
    "Outcome reporting is qualitative/summary; direction and magnitude of EMF effect on pain itself is not clearly quantified in the abstract.",
    "Potential mechanistic statements are speculative and not directly demonstrated in the abstract."
  ],
  "evidence_strength": "low",
  "confidence": 0.66,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "low intensity electromagnetic field",
    "EMF",
    "nitric oxide",
    "NO-synthase",
    "L-NAME",
    "sodium nitroprusside",
    "sodium nitrite",
    "formalin test",
    "tonic pain",
    "mice",
    "painful behavioural reaction"
  ],
  "suggested_hubs": []
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: Not supplied
PubMed: 16329392

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