Pulsed electromagnetic fields accelerate apoptotic rate in osteoclasts.

Connective tissue research · 2006 · Mixed · Low evidence

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MixedLow evidencePaper 5103

Osteoclasts exposed to 7.5 Hz PEMF (induced electric field intensity 3.0 mV/cm) showed a statistically significant increase in apoptotic rate after 8 hr (105%, p<0.001) and 16 hr (30%, p<0.05) exposures, while 1 hr exposure showed no statistically significant…

Study snapshot

PublicationConnective tissue research · 2006

Study typein_vitro

Reported directionMixed

Evidence ratingLow

Abstract

Selective control of cell function by applying specifically configured, low-energy, time-varying electromagnetic fields (EMF) has added a new, exciting dimension to biology and medicine. However, the mechanism involved is less clear. In our study, we investigated the effect of pulsed electromagnetic fields (PEMF) on induction of osteoclasts apoptosis. A statistically significant increase of apoptotic rate in osteoclasts (48 hr after isolation) was found when exposed to 7.5 Hz PEMF with induced electric fields intensity of 3.0 muv/cm for 8 (105%, p < 0.001) and 16 hr (30%, p < 0.05). However, exposure of osteoclasts to PEMF for only 1 hr showed no statistically significant differences. These findings suggest that PEMF have the ability to speed up apoptosis of osteoclasts derived from primary osteoblasts and bone marrow cells cocultures. This in vitro study, therefore, could be considered as groundwork for in vivo PEMF applications on some osteoclasts-associated bone diseases such as osteoporosis.

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typein_vitro

Effect directionmixed

PopulationNot supplied

Sample sizeNot supplied

ExposureELF · 1 hr, 8 hr, 16 hr exposures; apoptosis assessed 48 hr after isolation

Evidence strengthLowConfidence: 78% · Peer reviewed: yes

Main findings

Outcomes measured

Osteoclast apoptosis (apoptotic rate)

Limitations

In vitro study (mechanism and in vivo relevance not established in abstract)
Sample size not reported in abstract
Exposure metrics limited to frequency and induced electric field intensity; other dosimetry details not provided

View raw extracted JSON

{
  "study_type": "in_vitro",
  "exposure": {
    "band": "ELF",
    "source": "pulsed electromagnetic fields (PEMF)",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": "1 hr, 8 hr, 16 hr exposures; apoptosis assessed 48 hr after isolation"
  },
  "population": null,
  "sample_size": null,
  "outcomes": [
    "Osteoclast apoptosis (apoptotic rate)"
  ],
  "main_findings": "Osteoclasts exposed to 7.5 Hz PEMF (induced electric field intensity 3.0 mV/cm) showed a statistically significant increase in apoptotic rate after 8 hr (105%, p<0.001) and 16 hr (30%, p<0.05) exposures, while 1 hr exposure showed no statistically significant difference.",
  "effect_direction": "mixed",
  "limitations": [
    "In vitro study (mechanism and in vivo relevance not established in abstract)",
    "Sample size not reported in abstract",
    "Exposure metrics limited to frequency and induced electric field intensity; other dosimetry details not provided"
  ],
  "evidence_strength": "low",
  "confidence": 0.78,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "pulsed electromagnetic fields",
    "PEMF",
    "7.5 Hz",
    "induced electric field",
    "3.0 mV/cm",
    "osteoclasts",
    "apoptosis",
    "in vitro",
    "bone marrow cells",
    "coculture",
    "osteoporosis"
  ],
  "suggested_hubs": []
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1080/03008200600858783
PubMed: 16987754

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