Vitamin C and Vitamin E Protected B and Balb/c-3T3 Cells from Apoptosis Induced by Intermittent 50Hz ELF-EMF Radiation.

Iranian journal of public health · 2017 · Mixed · Low evidence

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MixedLow evidencePaper 4923

Study snapshot

PublicationIranian journal of public health · 2017

Study typein_vitro

Reported directionMixed

Evidence ratingLow

Abstract

BACKGROUND: The extremely low-frequency electromagnetic field (ELF-EMF), mainly emitted by electric transmission lines and household electronic appliances, is becoming a worldwide health risk. It is imperative to investigate the biological impacts of ELF-EMF and to identify products that are resistant to the radiation from 50 Hz ELF-EMF. In this study, we investigated the biological impacts of apoptosis caused by 50 Hz Power line ELF-EMF and the protective effects of Vit C and Vit E. METHODS: We conducted this study in Beijing, China in 2013. B and Balb/c-3T3 cells were divided into a sham group, an expo group and 3 expo groups in which the cells were preincubated with various concentrations of Vit C and Vit E. Then, all of the cells were exposed to 50 Hz Power line ELF-EMF and examined for apoptosis. The cells were collected for apoptosis detection after exposure. RESULTS: The percent of cells that undergoing apoptosis and preincubated with various concentrations of Vit C and Vit E were significantly lower than in the Expo group. CONCLUSION: Vit C and Vit E exert significant protective effects from 50 Hz ELF-EMF radiation. The optimal protective concentrations of Vit C and Vit E are 10 μmol/L and 25 μmol/L, respectively. The protective effect of vitamins was more apparent for Balb/c-3T3 cells than B cells.

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typein_vitro

Effect directionmixed

PopulationNot supplied

Sample sizeNot supplied

ExposureELF · 0.05 MHz

Evidence strengthLowConfidence: 78% · Peer reviewed: yes

Main findings

After exposure to 50 Hz power line ELF-EMF, cells preincubated with various concentrations of vitamin C and vitamin E had significantly lower percentages of apoptosis than the exposed (non-vitamin) group. The abstract reports optimal protective concentrations of 10 μmol/L (vitamin C) and 25 μmol/L (vitamin E), with a more apparent protective effect in Balb/c-3T3 cells than B cells.

Outcomes measured

Apoptosis in B cells
Apoptosis in Balb/c-3T3 cells
Protective effects of vitamin C preincubation
Protective effects of vitamin E preincubation

Limitations

Exposure intensity and duration are not reported in the abstract.
No sample size or number of replicates is provided in the abstract.
Only in vitro cell models were studied; findings may not generalize beyond these cell lines.
Details of apoptosis assay/methods are not described in the abstract.

View raw extracted JSON

{
  "study_type": "in_vitro",
  "exposure": {
    "band": "ELF",
    "source": "power line",
    "frequency_mhz": 0.05,
    "sar_wkg": null,
    "duration": null
  },
  "population": null,
  "sample_size": null,
  "outcomes": [
    "Apoptosis in B cells",
    "Apoptosis in Balb/c-3T3 cells",
    "Protective effects of vitamin C preincubation",
    "Protective effects of vitamin E preincubation"
  ],
  "main_findings": "After exposure to 50 Hz power line ELF-EMF, cells preincubated with various concentrations of vitamin C and vitamin E had significantly lower percentages of apoptosis than the exposed (non-vitamin) group. The abstract reports optimal protective concentrations of 10 μmol/L (vitamin C) and 25 μmol/L (vitamin E), with a more apparent protective effect in Balb/c-3T3 cells than B cells.",
  "effect_direction": "mixed",
  "limitations": [
    "Exposure intensity and duration are not reported in the abstract.",
    "No sample size or number of replicates is provided in the abstract.",
    "Only in vitro cell models were studied; findings may not generalize beyond these cell lines.",
    "Details of apoptosis assay/methods are not described in the abstract."
  ],
  "evidence_strength": "low",
  "confidence": 0.78,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "ELF-EMF",
    "50 Hz",
    "power line",
    "apoptosis",
    "vitamin C",
    "vitamin E",
    "B cells",
    "Balb/c-3T3",
    "in vitro"
  ],
  "suggested_hubs": [
    {
      "slug": "occupational-exposure",
      "weight": 0.2,
      "reason": "Exposure described as 50 Hz power line ELF-EMF; relevant to power-line related exposures, though the study is in vitro."
    }
  ]
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: Not supplied
PubMed: 28451526

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