Influence of the on-line ELF-EMF stimulation on the electrophysiological properties of the rat hippocampal CA1 neurons in vitro.

The Review of scientific instruments · 2017 · Mixed · Very low evidence

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MixedVery low evidencePaper 4901

Computational modeling (COMSOL) and measurements indicated similar magnetic flux densities generated by the on-line stimulation coils. On-line magnetic stimulation induced sodium channel currents and field excitatory postsynaptic potentials in rat hippocampal…

Study snapshot

PublicationThe Review of scientific instruments · 2017

Study typein_vitro

Reported directionMixed

Evidence ratingVery low

Abstract

The extremely low frequency electromagnetic fields (ELF-EMFs) have been shown to have an environmentally negative effect on humans' health; however, its treatment effect is beneficial for patients suffering from neurological disorders. Despite this success, the application of ELF-EMF has exceeded in the understanding of its internal mechanism. Recently, it was found that on-line magnetic stimulation may offer advantages over off-line magnetic exposure and has proven to be effective in activating the prefrontal cortex pyramidal neurons in vitro. Here, we perform computational simulations of the stimulation coils in COMSOL modeling to describe the uniformity of the distribution of the on-line magnetic field. Interestingly, the modeling data and actual measurements showed that the densities of the magnetic flux that was generated by the on-line stimulation coils were similar. The on-line magnetic stimulator induced sodium channel currents as well as field excitatory postsynaptic potentials of the rat hippocampal CA1 neurons and successfully demonstrated its extensive applications to activate neuronal tissue. These findings further raise the possibility that the instrument of on-line magnetic stimulation may be an effective alternative for studies in the field of bioelectromagnetics.

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typein_vitro

Effect directionmixed

PopulationRat hippocampal CA1 neurons in vitro

Sample sizeNot supplied

ExposureELF

Evidence strengthVery lowConfidence: 74% · Peer reviewed: yes

Main findings

Outcomes measured

Uniformity/distribution of magnetic field (COMSOL modeling and measurements)
Magnetic flux density generated by stimulation coils
Sodium channel currents
Field excitatory postsynaptic potentials (fEPSPs)

Limitations

No exposure parameters (e.g., frequency, intensity, duration) reported in the abstract
In vitro preparation; relevance to in vivo or human health outcomes not addressed in the abstract
Sample size and statistical details not provided in the abstract

View raw extracted JSON

{
  "study_type": "in_vitro",
  "exposure": {
    "band": "ELF",
    "source": "stimulation coils (on-line magnetic stimulation)",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": null
  },
  "population": "Rat hippocampal CA1 neurons in vitro",
  "sample_size": null,
  "outcomes": [
    "Uniformity/distribution of magnetic field (COMSOL modeling and measurements)",
    "Magnetic flux density generated by stimulation coils",
    "Sodium channel currents",
    "Field excitatory postsynaptic potentials (fEPSPs)"
  ],
  "main_findings": "Computational modeling (COMSOL) and measurements indicated similar magnetic flux densities generated by the on-line stimulation coils. On-line magnetic stimulation induced sodium channel currents and field excitatory postsynaptic potentials in rat hippocampal CA1 neurons in vitro.",
  "effect_direction": "mixed",
  "limitations": [
    "No exposure parameters (e.g., frequency, intensity, duration) reported in the abstract",
    "In vitro preparation; relevance to in vivo or human health outcomes not addressed in the abstract",
    "Sample size and statistical details not provided in the abstract"
  ],
  "evidence_strength": "very_low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "ELF-EMF",
    "extremely low frequency",
    "on-line magnetic stimulation",
    "stimulation coils",
    "COMSOL",
    "magnetic flux density",
    "hippocampus",
    "CA1",
    "rat",
    "in vitro",
    "sodium channel currents",
    "field excitatory postsynaptic potentials"
  ],
  "suggested_hubs": []
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1063/1.5006520
PubMed: 29092489

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