Effects of dietary green tea polyphenol supplementation on the health of workers exposed to high-voltage power lines.

Environmental toxicology and pharmacology · 2016 · Mixed · Moderate evidence

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MixedModerate evidencePaper 4833

Workers exposed to ELF-EMFs from 110–420 kV power lines had significantly increased urinary 8-isoprostane and 8-OHdG compared with non-exposed workers. These increases were diminished after 12 months of green tea polyphenol supplementation, but no protective …

Study snapshot

PublicationEnvironmental toxicology and pharmacology · 2016

Study typerandomized_trial

Reported directionMixed

Evidence ratingModerate

Abstract

Although it has been several decades since the focus on the effect of extremely low frequency electromagnetic fields (ELF-EMF) of high-voltage power lines on human health, no consistent conclusion has been drawn. The present study aimed to investigate the change in oxidative stress after exposure to ELF-EMFs, and potential protective effects of green tea polyphenol supplementation (GTPS) on ELF-EMFs induced oxidative stress. A total of 867 subjects, including workers with or without exposure to ELF-EMFs of 110-420kV power lines, participated and were randomized into GTPS and placebo treatment groups. Oxidative stress and oxidative damage to DNA were assessed by urinary tests of 8-isoprostane and 8-OHdG. Significant increased urinary 8-isoprostane and 8-OHdG were observed in workers with ELF-EMFs exposure, which were diminished after 12 months of GTPS. No protective effects of GTPS on oxidative stress and oxidative damage to DNA were observed after three months of GTPS withdraw. We found a negative impact of high-voltage power lines on the health of workers. Long-term GTPS could be an efficient protection against the health issues induced by high-voltage power lines.

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typerandomized_trial

Effect directionmixed

PopulationWorkers with or without exposure to ELF-EMFs of 110–420 kV power lines

Sample size867

ExposureELF · 12 months (GTPS intervention); effects also assessed after 3 months withdrawal

Evidence strengthModerateConfidence: 74% · Peer reviewed: yes

Main findings

Outcomes measured

Urinary 8-isoprostane (oxidative stress)
Urinary 8-OHdG (oxidative DNA damage)

Limitations

Frequency and field strength/exposure metrics for ELF-EMF were not reported in the abstract
Details of randomization, blinding, and allocation concealment were not provided in the abstract
Baseline comparability and potential confounders between exposed and non-exposed workers were not described in the abstract
Clinical health outcomes were not specified; outcomes were limited to urinary biomarkers

View raw extracted JSON

{
  "study_type": "randomized_trial",
  "exposure": {
    "band": "ELF",
    "source": "occupational",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": "12 months (GTPS intervention); effects also assessed after 3 months withdrawal"
  },
  "population": "Workers with or without exposure to ELF-EMFs of 110–420 kV power lines",
  "sample_size": 867,
  "outcomes": [
    "Urinary 8-isoprostane (oxidative stress)",
    "Urinary 8-OHdG (oxidative DNA damage)"
  ],
  "main_findings": "Workers exposed to ELF-EMFs from 110–420 kV power lines had significantly increased urinary 8-isoprostane and 8-OHdG compared with non-exposed workers. These increases were diminished after 12 months of green tea polyphenol supplementation, but no protective effects were observed after three months of supplementation withdrawal.",
  "effect_direction": "mixed",
  "limitations": [
    "Frequency and field strength/exposure metrics for ELF-EMF were not reported in the abstract",
    "Details of randomization, blinding, and allocation concealment were not provided in the abstract",
    "Baseline comparability and potential confounders between exposed and non-exposed workers were not described in the abstract",
    "Clinical health outcomes were not specified; outcomes were limited to urinary biomarkers"
  ],
  "evidence_strength": "moderate",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "extremely low frequency electromagnetic fields",
    "ELF-EMF",
    "high-voltage power lines",
    "occupational exposure",
    "oxidative stress",
    "8-isoprostane",
    "8-OHdG",
    "oxidative DNA damage",
    "green tea polyphenols",
    "supplementation",
    "placebo",
    "randomized controlled trial"
  ],
  "suggested_hubs": [
    {
      "slug": "occupational-exposure",
      "weight": 0.9,
      "reason": "Study population is workers exposed to high-voltage power lines (occupational ELF-EMF exposure)."
    }
  ]
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1016/j.etap.2016.07.016
PubMed: 27490209

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