Effect of Extremely Low Frequency Electromagnetic Field and/or GABAB Receptors on Foot Shock-induced Aggression in Rats.

Basic and clinical neuroscience · 2014 · No effect · Low evidence

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No effectLow evidencePaper 4655

Study snapshot

PublicationBasic and clinical neuroscience · 2014

Study typeanimal

Reported directionNo effect

Evidence ratingLow

Abstract

INTRODUCTION: The present study investigated the interactive effect of GABAB receptors and extremely low frequency electromagnetic field (ELF-EMF) on foot shock-induced aggression in rats. METHODS: Fifty adult male rats were randomly assigned into 10 groups. Groups 2, 4, 6, 8 and 10 were exposed to 50 Hz, 500 µT ELF-EMF for 30 days 8h per day while the remaining groups (1, 3, 5, 7 and 9) were sham-exposed. At the end of this period, the animals in groups 1 and 2 received normal saline while groups 3 and 4 treated with 100 mg/kg (low dose) of CGP35348 and groups 5 and 6 injected with 200 mg/kg (high dose) of CGP35348. Groups 7 and 8 treated with 1.7 mg/kg (low dose) of Baclofen and groups 9 and 10 received 3 mg/kg (high dose) Baclofen by IP injections. Twenty min after the injection, the aggressive behavior was recorded in foot shock-induced aggression model. The number of lateral threat, lifted up threat, biting, attacking, chasing and approaching were considered as paradigms of aggressive behavior. RESULTS: ELF-EMF, Baclofen or CGP35348 alone had no significant effect on aggressive behavior. Except that rats exposed and treated with low dose of CGP35348 demonstrated significantly higher numbers of only one of the paradigms of aggressive behavior (lifted up threats), CGP35348 and Baclofen in both doses in combination with ELF-EMF exposure had no significant effect on aggression. DISCUSSION: GABAB receptors and ELF-EMFs had no effect (both enhancement and suppression) on aggressive behavior of rats in foot shock-induced model of aggression.

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Study typeanimal

Effect directionno_effect

PopulationAdult male rats

Sample size50

ExposureELF · 0.05 MHz · 30 days, 8 h/day

Evidence strengthLowConfidence: 78% · Peer reviewed: yes

Main findings

Rats exposed to 50 Hz, 500 µT ELF-EMF for 30 days showed no significant changes in foot shock-induced aggressive behaviors compared with sham exposure. Baclofen or CGP35348 alone had no significant effects; in combination with ELF-EMF, both drugs (both doses) also showed no significant effects, except an increase in lifted up threats in the ELF-EMF + low-dose CGP35348 group.

Outcomes measured

Foot shock-induced aggressive behavior (lateral threat, lifted up threat, biting, attacking, chasing, approaching)

View raw extracted JSON

{
  "study_type": "animal",
  "exposure": {
    "band": "ELF",
    "source": null,
    "frequency_mhz": 0.05,
    "sar_wkg": null,
    "duration": "30 days, 8 h/day"
  },
  "population": "Adult male rats",
  "sample_size": 50,
  "outcomes": [
    "Foot shock-induced aggressive behavior (lateral threat, lifted up threat, biting, attacking, chasing, approaching)"
  ],
  "main_findings": "Rats exposed to 50 Hz, 500 µT ELF-EMF for 30 days showed no significant changes in foot shock-induced aggressive behaviors compared with sham exposure. Baclofen or CGP35348 alone had no significant effects; in combination with ELF-EMF, both drugs (both doses) also showed no significant effects, except an increase in lifted up threats in the ELF-EMF + low-dose CGP35348 group.",
  "effect_direction": "no_effect",
  "limitations": [],
  "evidence_strength": "low",
  "confidence": 0.78,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "ELF-EMF",
    "50 Hz",
    "500 µT",
    "rats",
    "aggression",
    "foot shock-induced aggression",
    "GABAB receptors",
    "baclofen",
    "CGP35348"
  ],
  "suggested_hubs": []
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: Not supplied
PubMed: 25337376

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