RF Safe

Microwave electromagnetic field regulates gene expression in T-lymphoblastoid leukemia CCRF-CEM cell line exposed to 900 MHz.

Electromagnetic biology and medicine · 2012 · Unclear · Insufficient evidence

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UnclearInsufficient evidencePaper 4547

Acute T-lymphoblastoid leukemia (CCRF-CEM) cells were cultured in the presence of 900 MHz microwave EMF generated by a TEM cell at short and long exposure times, and gene expression and functional pathways influenced by exposure were evaluated.

Study snapshot

PublicationElectromagnetic biology and medicine · 2012
Study typein_vitro
Reported directionUnclear
Evidence ratingInsufficient

Abstract

Electric, magnetic, and electromagnetic fields are ubiquitous in our society, and concerns have been expressed regarding possible adverse effects of these exposures. Research on Extremely Low-Frequency (ELF) magnetic fields has been performed for more than two decades, and the methodology and quality of studies have improved over time. Studies have consistently shown increased risk for childhood leukemia associated with ELF magnetic fields. There are still inadequate data for other outcomes. More recently, focus has shifted toward Radio Frequencies (RF) exposures from mobile telephony. There are no persuasive data suggesting a health risk, but this research field is still immature with regard to the quantity and quality of available data. This technology is constantly changing and there is a need for continued research on this issue. To investigate whether exposure to high-frequency electromagnetic fields (EMF) could induce adverse health effects, we cultured acute T-lymphoblastoid leukemia cells (CCRF-CEM) in the presence of 900 MHz MW-EMF generated by a transverse electromagnetic (TEM) cell at short and long exposure times. We evaluated the effect of high-frequency EMF on gene expression and we identified functional pathways influenced by 900 MHz MW-EMF exposure.

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typein_vitro
Effect directionunclear
PopulationAcute T-lymphoblastoid leukemia CCRF-CEM cell line
Sample sizeNot supplied
ExposureRF · 900 MHz · short and long exposure times
Evidence strengthInsufficientConfidence: 62% · Peer reviewed: yes

Main findings

Acute T-lymphoblastoid leukemia (CCRF-CEM) cells were cultured in the presence of 900 MHz microwave EMF generated by a TEM cell at short and long exposure times, and gene expression and functional pathways influenced by exposure were evaluated.

Outcomes measured

  • Gene expression
  • Functional pathways influenced by exposure

Limitations

  • No quantitative results or direction of gene expression changes reported in the abstract
  • No SAR or exposure intensity details provided in the abstract
  • Sample size not reported in the abstract
View raw extracted JSON
{
  "study_type": "in_vitro",
  "exposure": {
    "band": "RF",
    "source": null,
    "frequency_mhz": 900,
    "sar_wkg": null,
    "duration": "short and long exposure times"
  },
  "population": "Acute T-lymphoblastoid leukemia CCRF-CEM cell line",
  "sample_size": null,
  "outcomes": [
    "Gene expression",
    "Functional pathways influenced by exposure"
  ],
  "main_findings": "Acute T-lymphoblastoid leukemia (CCRF-CEM) cells were cultured in the presence of 900 MHz microwave EMF generated by a TEM cell at short and long exposure times, and gene expression and functional pathways influenced by exposure were evaluated.",
  "effect_direction": "unclear",
  "limitations": [
    "No quantitative results or direction of gene expression changes reported in the abstract",
    "No SAR or exposure intensity details provided in the abstract",
    "Sample size not reported in the abstract"
  ],
  "evidence_strength": "insufficient",
  "confidence": 0.62,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "900 MHz",
    "microwave EMF",
    "RF exposure",
    "TEM cell",
    "CCRF-CEM",
    "T-lymphoblastoid leukemia",
    "gene expression",
    "in vitro"
  ],
  "suggested_hubs": []
}
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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.3109/15368378.2011.596251
PubMed: 22332889

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