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New clinical findings on the longevity gene in disease, health, & longevity: Sirtuin 1 often decreases with advanced age & serious diseases in most parts of the human body, while relatively high & constant Sirtuin 1 regardless of age was first found in the hippocampus of supercentenarians.

Acupuncture & electro-therapeutics research · 2011 · Unclear · Very low evidence

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UnclearVery low evidencePaper 4478

Sirtuin 1 expression was reported as measured non-invasively using an EMF resonance phenomenon involving a polyclonal antibody and Sirt1 in the body. In over 100 adults (20–122 years), most body regions showed Sirt1 levels of 5–10 pg BDORT units; Sirt1 <1 pg …

Study snapshot

PublicationAcupuncture & electro-therapeutics research · 2011
Study typecross_sectional
Reported directionUnclear
Evidence ratingVery low

Abstract

The expression of the longevity gene, Sirtuin 1, was non-invasively measured using Electro-Magnetic Field (EMF) resonance phenomenon between a known amount of polyclonal antibody of the C-terminal of Sirtuin 1 & Sirtuin 1 molecule inside of the body. Our measurement of over 100 human adult males and females, ranging between 20-122 years old, indicated that the majority of subjects had Sirtuin 1 levels of 5-10 pg BDORT units in most parts of the body. When Sirtuin 1 was less than 1 pg, the majority of the people had various degrees of tumors or other serious diseases. When Sirtuin 1 levels were less than 0.25 pg BDORT units, a high incidence of AIDS was also detected. Very few people had Sirtuin 1 levels of over 25 pg BDORT units in most parts of the body. We selected 7 internationally recognized supercentenarians who lived between 110-122 years old. To our surprise, most of their body Sirtuin 1 levels were between 2.5-10 pg BDORT units. However, by evaluating different parts of the brain, we found that both sides of the Hippocampus had a much higher amount of Sirtuin 1, between 25-100 pg BDORT units. With most subjects, Sirtuin 1 was found to be higher in the Hippocampus than in the rest of the body and remains relatively constant regardless of age. We found that Aspartame, plastic eye contact lenses, and asbestos in dental apparatuses, which reduce normal cell telomeres, also significantly reduce Sirtuin 1. In addition, we found that increasing normal cell telomere by electrical or mechanical stimulation of True ST-36 increases the expression of the Sirtuin 1 gene in people in which expression is low. This measurement of Sirtuin 1 in the Hippocampus has become a reliable indicator for detecting potential longevity of an individual.

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typecross_sectional
Effect directionunclear
PopulationHuman adult males and females (ages 20–122), including 7 supercentenarians (ages 110–122)
Sample size100
ExposureNot supplied
Evidence strengthVery lowConfidence: 62% · Peer reviewed: yes

Main findings

Sirtuin 1 expression was reported as measured non-invasively using an EMF resonance phenomenon involving a polyclonal antibody and Sirt1 in the body. In over 100 adults (20–122 years), most body regions showed Sirt1 levels of 5–10 pg BDORT units; Sirt1 <1 pg was reported to be associated with tumors or other serious diseases, and Sirt1 <0.25 pg with a high incidence of AIDS. In 7 supercentenarians, most body Sirt1 levels were 2.5–10 pg, but hippocampal Sirt1 was much higher (25–100 pg) and described as relatively constant regardless of age; electrical/mechanical stimulation of True ST-36 was reported to increase Sirt1 in people with low expression.

Outcomes measured

  • Sirtuin 1 (Sirt1) expression levels (pg BDORT units) in body regions including hippocampus
  • Associations of low Sirt1 with tumors/serious diseases and AIDS incidence
  • Reported effects of aspartame, plastic eye contact lenses, asbestos in dental apparatuses on Sirt1
  • Reported effect of electrical or mechanical stimulation of True ST-36 on Sirt1 expression

Limitations

  • Study design and sampling approach are not described beyond counts/age range; representativeness is unclear.
  • No statistical methods, effect sizes, or uncertainty measures are reported in the abstract.
  • Exposure characterization for the EMF resonance measurement (e.g., frequency, field strength) is not provided.
  • Causal claims (e.g., stimulation increasing Sirt1; substances reducing Sirt1) are not supported with methodological detail in the abstract.
  • Outcome units ("pg BDORT units") and validation of the measurement approach are not described in the abstract.
View raw extracted JSON
{
  "study_type": "cross_sectional",
  "exposure": {
    "band": null,
    "source": "other",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": null
  },
  "population": "Human adult males and females (ages 20–122), including 7 supercentenarians (ages 110–122)",
  "sample_size": 100,
  "outcomes": [
    "Sirtuin 1 (Sirt1) expression levels (pg BDORT units) in body regions including hippocampus",
    "Associations of low Sirt1 with tumors/serious diseases and AIDS incidence",
    "Reported effects of aspartame, plastic eye contact lenses, asbestos in dental apparatuses on Sirt1",
    "Reported effect of electrical or mechanical stimulation of True ST-36 on Sirt1 expression"
  ],
  "main_findings": "Sirtuin 1 expression was reported as measured non-invasively using an EMF resonance phenomenon involving a polyclonal antibody and Sirt1 in the body. In over 100 adults (20–122 years), most body regions showed Sirt1 levels of 5–10 pg BDORT units; Sirt1 <1 pg was reported to be associated with tumors or other serious diseases, and Sirt1 <0.25 pg with a high incidence of AIDS. In 7 supercentenarians, most body Sirt1 levels were 2.5–10 pg, but hippocampal Sirt1 was much higher (25–100 pg) and described as relatively constant regardless of age; electrical/mechanical stimulation of True ST-36 was reported to increase Sirt1 in people with low expression.",
  "effect_direction": "unclear",
  "limitations": [
    "Study design and sampling approach are not described beyond counts/age range; representativeness is unclear.",
    "No statistical methods, effect sizes, or uncertainty measures are reported in the abstract.",
    "Exposure characterization for the EMF resonance measurement (e.g., frequency, field strength) is not provided.",
    "Causal claims (e.g., stimulation increasing Sirt1; substances reducing Sirt1) are not supported with methodological detail in the abstract.",
    "Outcome units (\"pg BDORT units\") and validation of the measurement approach are not described in the abstract."
  ],
  "evidence_strength": "very_low",
  "confidence": 0.62,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "Sirtuin 1",
    "SIRT1",
    "longevity gene",
    "hippocampus",
    "supercentenarians",
    "EMF resonance",
    "BDORT units",
    "telomere",
    "ST-36",
    "electrical stimulation",
    "mechanical stimulation"
  ],
  "suggested_hubs": []
}
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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.3727/036012911803634111
PubMed: 22443029

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