Extremely low-frequency electromagnetic fields differentially regulate estrogen receptor-alpha and -beta expression in the rat olfactory bulb.

Neuroscience letters · 2010 · Mixed · Low evidence

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MixedLow evidencePaper 4396

ELF EMF exposure modulated estrogen receptor-beta mRNA expression in the olfactory bulb of adult female rats in a biphasic manner depending on estrous cycle phase, but did not affect estrogen receptor-alpha mRNA expression in females or either receptor expres…

Study snapshot

PublicationNeuroscience letters · 2010

Study typeanimal

Reported directionMixed

Evidence ratingLow

Abstract

Recently, the effects of extremely low-frequency electromagnetic fields (ELF EMF) on biological systems have been extensively investigated. In this report, the influence of ELF EMF on olfactory bulb (OB) estrogen receptor-alpha (ER alpha) mRNA and -beta (ER beta) mRNA expression was studied by RT-PCR in adult female and male rats. Results reveal for the first time that ELF EMF exerted a biphasic effect on female OB ER beta mRNA gene expression, which increased during diestrous and decreased during estrous. We did not observe any influence of ELF EMF on female OB ER alpha mRNA expression. Our data demonstrate a fluctuating pattern of ER-alpha and -beta mRNA expression in the female OB throughout the phases of the estrous cycle in non-ELF EMF-exposed animals. Thus the highest ER alpha expression was observed in diestrous and the lowest in proestrous. The pattern of ER beta mRNA was less variable, the lowest expression was observed in diestrous. ER-alpha mRNA and -beta mRNA expression level in the male OB did not exhibit any variation either in ELF EMF-exposed or non-ELF EMF-exposed animals. In summary, ELF EMF modulate ER beta gene expression in the OB of female adult rats but not in males.

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal

Effect directionmixed

Populationadult female and male rats

Sample sizeNot supplied

ExposureELF

Evidence strengthLowConfidence: 50% · Peer reviewed: yes

Main findings

Outcomes measured

olfactory bulb estrogen receptor-alpha mRNA expression
olfactory bulb estrogen receptor-beta mRNA expression

Limitations

No sample size reported
No exposure duration or intensity details
Animal study, limiting direct human relevance

View raw extracted JSON

{
  "study_type": "animal",
  "exposure": {
    "band": "ELF",
    "source": null,
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": null
  },
  "population": "adult female and male rats",
  "sample_size": null,
  "outcomes": [
    "olfactory bulb estrogen receptor-alpha mRNA expression",
    "olfactory bulb estrogen receptor-beta mRNA expression"
  ],
  "main_findings": "ELF EMF exposure modulated estrogen receptor-beta mRNA expression in the olfactory bulb of adult female rats in a biphasic manner depending on estrous cycle phase, but did not affect estrogen receptor-alpha mRNA expression in females or either receptor expression in males.",
  "effect_direction": "mixed",
  "limitations": [
    "No sample size reported",
    "No exposure duration or intensity details",
    "Animal study, limiting direct human relevance"
  ],
  "evidence_strength": "low",
  "confidence": 0.5,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "ELF EMF",
    "estrogen receptor",
    "olfactory bulb",
    "rat",
    "gene expression",
    "sex differences"
  ],
  "suggested_hubs": []
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1016/j.neulet.2010.01.021
PubMed: 20085801

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