RF Safe

Electric and magnetic fields do not modify the biochemical properties of FRTL-5 cells.

Journal of endocrinological investigation · 2011 · No effect · Low evidence

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No effectLow evidencePaper 4373

Exposure of FRTL-5 thyroid cells to a GSM radiofrequency signal at 900 MHz for 24, 48, and 96 hours did not influence cAMP production and did not modify iodide accumulation compared with basal conditions.

Study snapshot

PublicationJournal of endocrinological investigation · 2011
Study typein_vitro
Reported directionNo effect
Evidence ratingLow

Abstract

BACKGROUND: Electric and magnetic fields (EMF) might be involved in human disease and numerous research and scientific reviews have been conducted to address this question. In particular thyroid structural and functional alterations caused by various forms of non-ionizing radiation have been described. AIM: The aim of this study was to analyze the possible effects of EMF on thyroid, in particular we analyzed the effects caused by a GSM (Global System for Mobile Communications) signal (900 MHz) on cultured thyroid cells (FRTL- 5). MATERIAL AND METHODS: The experimental setup was designed in order to expose samples to a radiofrequency wave in well-controlled conditions. We used the FRTL-5 cell line, an epithelial monoclonal continuous cell line derived from Fisher rat thyroid tissue growing as monolayer, expressing the TSH receptor and the sodium-iodide symporter (NIS). FRTL-5 were subsequently irradiate for 24, 48, and 96 h with EMF (800-900 MHz, power-frequency of mobile communication systems) and iodide uptake and cAMP production were measured. RESULTS: The irradiation of cells with EMF at 900 Mhz for 24, 48, and 96 h did not influence the level of cAMP production and was not able to modify iodide accumulation in FRTL- 5 cells with respect to basal conditions. CONCLUSIONS: In conclusion, EMF do not seem to be able to interfere with the biochemical properties of FRTL-5 cells in vitro.

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typein_vitro
Effect directionno_effect
PopulationFRTL-5 cultured thyroid cells (rat thyroid cell line)
Sample sizeNot supplied
ExposureRF · 900 MHz · 24, 48, and 96 h
Evidence strengthLowConfidence: 78% · Peer reviewed: yes

Main findings

Exposure of FRTL-5 thyroid cells to a GSM radiofrequency signal at 900 MHz for 24, 48, and 96 hours did not influence cAMP production and did not modify iodide accumulation compared with basal conditions.

Outcomes measured

  • cAMP production
  • iodide uptake/accumulation

Limitations

  • In vitro cell-line study (FRTL-5)
  • No sample size reported in abstract
  • No SAR/dosimetry details reported in abstract
View raw extracted JSON
{
  "study_type": "in_vitro",
  "exposure": {
    "band": "RF",
    "source": "GSM (mobile communication signal)",
    "frequency_mhz": 900,
    "sar_wkg": null,
    "duration": "24, 48, and 96 h"
  },
  "population": "FRTL-5 cultured thyroid cells (rat thyroid cell line)",
  "sample_size": null,
  "outcomes": [
    "cAMP production",
    "iodide uptake/accumulation"
  ],
  "main_findings": "Exposure of FRTL-5 thyroid cells to a GSM radiofrequency signal at 900 MHz for 24, 48, and 96 hours did not influence cAMP production and did not modify iodide accumulation compared with basal conditions.",
  "effect_direction": "no_effect",
  "limitations": [
    "In vitro cell-line study (FRTL-5)",
    "No sample size reported in abstract",
    "No SAR/dosimetry details reported in abstract"
  ],
  "evidence_strength": "low",
  "confidence": 0.78,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "EMF",
    "radiofrequency",
    "GSM",
    "900 MHz",
    "thyroid cells",
    "FRTL-5",
    "cAMP",
    "iodide uptake",
    "NIS",
    "TSH receptor"
  ],
  "suggested_hubs": []
}
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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1007/bf03347064
PubMed: 20543553

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