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Electric field suppression of epileptiform activity in hippocampal slices.

Journal of neurophysiology · 1996 · Benefit · Low evidence

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BenefitLow evidencePaper 4205

Relatively small external DC electric fields suppressed epileptiform activity in 31 of 33 hippocampal slices. Suppression depended strongly on field orientation relative to the apical dendritic-somatic axis and was observed at field strengths ≤5–10 mV/mm, wit…

Study snapshot

PublicationJournal of neurophysiology · 1996
Study typein_vitro
Reported directionBenefit
Evidence ratingLow

Abstract

1. The effects of relatively small external DC electric fields on synchronous activity in CA1 and CA3 from transverse and longitudinal type hippocampal slices were studied. 2. To record neuronal activity during significant field changes, differential DC amplification was employed with a reference electrode aligned along an isopotential with the recording electrode. 3. Suppression of epileptiform activity was observed in 31 of 33 slices independent of region studied and type of slice but was highly dependent on field orientation with respect to the apical dendritic-somatic axis. 4. Modulation of neuronal activity in these experiments was readily observed at field strengths < or = 5-10 mV/mm. Suppression was seen with the field oriented (positive to negative potential) from the soma to the apical dentrites. 5. In vivo application of these results may be feasible.

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typein_vitro
Effect directionbenefit
PopulationHippocampal slices (CA1 and CA3; transverse and longitudinal)
Sample size33
Exposure0 MHz
Evidence strengthLowConfidence: 74% · Peer reviewed: yes

Main findings

Relatively small external DC electric fields suppressed epileptiform activity in 31 of 33 hippocampal slices. Suppression depended strongly on field orientation relative to the apical dendritic-somatic axis and was observed at field strengths ≤5–10 mV/mm, with suppression when the field was oriented from soma to apical dendrites (positive to negative potential).

Outcomes measured

  • synchronous neuronal activity
  • epileptiform activity suppression
  • dependence on field orientation
  • field strength threshold for modulation

Limitations

  • In vitro hippocampal slice preparation; in vivo relevance not established in the abstract
  • Field effects were highly dependent on orientation, which may limit generalizability
  • Exposure duration not reported
View raw extracted JSON
{
  "study_type": "in_vitro",
  "exposure": {
    "band": null,
    "source": "external DC electric field",
    "frequency_mhz": 0,
    "sar_wkg": null,
    "duration": null
  },
  "population": "Hippocampal slices (CA1 and CA3; transverse and longitudinal)",
  "sample_size": 33,
  "outcomes": [
    "synchronous neuronal activity",
    "epileptiform activity suppression",
    "dependence on field orientation",
    "field strength threshold for modulation"
  ],
  "main_findings": "Relatively small external DC electric fields suppressed epileptiform activity in 31 of 33 hippocampal slices. Suppression depended strongly on field orientation relative to the apical dendritic-somatic axis and was observed at field strengths ≤5–10 mV/mm, with suppression when the field was oriented from soma to apical dendrites (positive to negative potential).",
  "effect_direction": "benefit",
  "limitations": [
    "In vitro hippocampal slice preparation; in vivo relevance not established in the abstract",
    "Field effects were highly dependent on orientation, which may limit generalizability",
    "Exposure duration not reported"
  ],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "DC electric field",
    "hippocampal slice",
    "CA1",
    "CA3",
    "epileptiform activity",
    "field orientation",
    "neuronal modulation"
  ],
  "suggested_hubs": []
}
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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1152/jn.1996.76.6.4202
PubMed: 8985916

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