[Effect of electric field on erythrocyte sedimentation rate. VI--dependence of electric field pattern].

Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 1997 · Mixed · Low evidence

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MixedLow evidencePaper 4098

Study snapshot

PublicationSheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 1997

Study typeother

Reported directionMixed

Evidence ratingLow

Abstract

An automatic analyzer of RBC rheological parameters and a microscopic morphological observation technique were employed to investigate the effect of three electric field patterns on erythrocyte sedimentation and aggregation in a physiological saline solution and in autologous plasma, respectively. Experimental results indicate that in a physiological saline solution: 1) Erythrocytes present a lightly aggregation and settle faster by an alternative current electric field; 2) There exists no erythrocyte aggregation by a direct current electric field of constant current and the enhancement of erythrocyte sedimentation is caused only by the action of electric force; 3) Time courses of erythrocyte sedimentation fit well with an exponential type curve by a direct current electric field of constant voltage, and this exponential type sedimentation curve is not caused by erythrocyte aggregation but caused by the decrease of circuit current with time duration. Also shown by experimental results is that the above three electric field patterns all affect the erythrocyte sedimentation in antologous plasma in different contents, which predicts some change in erythrocyte aggregation behavior in autologous plasma by an external electric field.

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeother

Effect directionmixed

PopulationNot supplied

Sample sizeNot supplied

ExposureNot supplied

Evidence strengthLowConfidence: 74% · Peer reviewed: yes

Main findings

Using an automatic analyzer and microscopic observation, the study compared three electric field patterns. In physiological saline, an AC electric field produced light erythrocyte aggregation and faster settling; a DC constant-current field produced no aggregation and increased sedimentation attributed to electric force; and a DC constant-voltage field produced an exponential sedimentation time course attributed to decreasing circuit current rather than aggregation. The three field patterns also affected erythrocyte sedimentation in autologous plasma to different extents, suggesting changes in aggregation behavior in plasma under external electric fields.

Outcomes measured

erythrocyte sedimentation rate
erythrocyte aggregation
erythrocyte morphology (microscopic observation)
RBC rheological parameters

Limitations

No electric field strength/intensity reported in abstract
No frequency specified for the AC field in abstract
Sample size and subject/donor details not reported
Primarily in vitro/ex vivo conditions (physiological saline and autologous plasma) may limit generalizability

View raw extracted JSON

{
  "study_type": "other",
  "exposure": {
    "band": null,
    "source": "external electric field (AC and DC patterns)",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": null
  },
  "population": null,
  "sample_size": null,
  "outcomes": [
    "erythrocyte sedimentation rate",
    "erythrocyte aggregation",
    "erythrocyte morphology (microscopic observation)",
    "RBC rheological parameters"
  ],
  "main_findings": "Using an automatic analyzer and microscopic observation, the study compared three electric field patterns. In physiological saline, an AC electric field produced light erythrocyte aggregation and faster settling; a DC constant-current field produced no aggregation and increased sedimentation attributed to electric force; and a DC constant-voltage field produced an exponential sedimentation time course attributed to decreasing circuit current rather than aggregation. The three field patterns also affected erythrocyte sedimentation in autologous plasma to different extents, suggesting changes in aggregation behavior in plasma under external electric fields.",
  "effect_direction": "mixed",
  "limitations": [
    "No electric field strength/intensity reported in abstract",
    "No frequency specified for the AC field in abstract",
    "Sample size and subject/donor details not reported",
    "Primarily in vitro/ex vivo conditions (physiological saline and autologous plasma) may limit generalizability"
  ],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "electric field",
    "alternating current",
    "direct current",
    "constant current",
    "constant voltage",
    "erythrocyte sedimentation",
    "erythrocyte aggregation",
    "RBC rheology",
    "autologous plasma",
    "physiological saline"
  ],
  "suggested_hubs": [
    {
      "slug": "in-vitro",
      "weight": 0.78,
      "reason": "Experiments conducted in physiological saline solution and autologous plasma with measured RBC parameters under applied electric fields."
    }
  ]
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: Not supplied
PubMed: 11326840

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