Magnetic field perturbations as a tool for controlling enzyme-regulated and oscillatory biochemical reactions.

Biophysical chemistry · 1998 · Mixed · Very low evidence

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MixedVery low evidencePaper 4044

Study snapshot

PublicationBiophysical chemistry · 1998

Study typeother

Reported directionMixed

Evidence ratingVery low

Abstract

The feasibility of magnetic field perturbations as a tool for controlling enzyme-regulated and oscillatory biochemical reactions is studied. Our approach is based on recent experimental results that revealed magnetic field effects on the in vitro activity of enzyme systems in accordance with the radical pair mechanism. A minimum model consisting of two coupled enzyme-regulated reactions is discussed that combines, in a self-consistent manner, magnetic field-sensitive enzyme kinetics with non-linear dynamical principles. Furthermore, a simple detector mechanism is described that is capable of responding to an oscillatory input. Results reveal that moderate-strength magnetic fields (B=1-100 mT) may effectively alter the dynamics of the system. In particular, a response behavior is observed that depends on: (1) the combination of static and time-varying magnetic fields; (2) the field amplitude; and (3) the field frequency in a non-linear fashion. The specific response behavior is critically determined by the biochemical boundary conditions as defined by the kinetic properties of the system. We propose an experimental implementation of the results based on the oscillatory peroxidase-oxidase reaction controlled by the enzyme horseradish peroxidase.

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeother

Effect directionmixed

PopulationNot supplied

Sample sizeNot supplied

ExposureNot supplied

Evidence strengthVery lowConfidence: 74% · Peer reviewed: yes

Main findings

A theoretical/minimum-model analysis suggests that moderate-strength magnetic fields (B=1–100 mT), including combinations of static and time-varying fields, may alter the dynamics of coupled enzyme-regulated reactions in a nonlinear manner depending on field amplitude, field frequency, and biochemical boundary conditions. The authors propose an experimental implementation using the oscillatory peroxidase-oxidase reaction controlled by horseradish peroxidase.

Outcomes measured

Dynamics/control of enzyme-regulated and oscillatory biochemical reactions
In vitro enzyme activity/kinetics (radical pair mechanism context)

Limitations

Appears to be a modeling/theoretical study rather than reporting new experimental results
No sample size or empirical effect estimates reported in the abstract
Frequency range for the time-varying field is not specified in the abstract

View raw extracted JSON

{
  "study_type": "other",
  "exposure": {
    "band": null,
    "source": "laboratory magnetic field perturbations (static and time-varying)",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": null
  },
  "population": null,
  "sample_size": null,
  "outcomes": [
    "Dynamics/control of enzyme-regulated and oscillatory biochemical reactions",
    "In vitro enzyme activity/kinetics (radical pair mechanism context)"
  ],
  "main_findings": "A theoretical/minimum-model analysis suggests that moderate-strength magnetic fields (B=1–100 mT), including combinations of static and time-varying fields, may alter the dynamics of coupled enzyme-regulated reactions in a nonlinear manner depending on field amplitude, field frequency, and biochemical boundary conditions. The authors propose an experimental implementation using the oscillatory peroxidase-oxidase reaction controlled by horseradish peroxidase.",
  "effect_direction": "mixed",
  "limitations": [
    "Appears to be a modeling/theoretical study rather than reporting new experimental results",
    "No sample size or empirical effect estimates reported in the abstract",
    "Frequency range for the time-varying field is not specified in the abstract"
  ],
  "evidence_strength": "very_low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "magnetic fields",
    "static magnetic field",
    "time-varying magnetic field",
    "enzyme kinetics",
    "oscillatory reactions",
    "radical pair mechanism",
    "peroxidase-oxidase reaction",
    "horseradish peroxidase",
    "nonlinear dynamics"
  ],
  "suggested_hubs": []
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1016/s0301-4622(98)00180-x
PubMed: 17029747

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