Accurate linear radiofrequency lesions guided by a nonfluoroscopic electroanatomic mapping method during atrial fibrillation.

Pacing and clinical electrophysiology : PACE · 2001 · Unclear · Low evidence

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UnclearLow evidencePaper 3913

In 14 cases, the location, shape, length, and continuity of linear lesions on electroanatomic maps highly correlated with autopsy findings. Average line length on reconstructed maps (32.3±4.1 mm) highly correlated with pathological specimen measurements (31.7…

Study snapshot

PublicationPacing and clinical electrophysiology : PACE · 2001

Study typeanimal

Reported directionUnclear

Evidence ratingLow

Abstract

Catheter-based continuous linear lesions may become a curative procedure for AF. The accuracy of guiding the application of continuous RF lesions by a nonfluoroscopic mapping system (NFM) during AF in goats was tested. The NFM system (Carto) uses magnetic fields to determine, in real time, the location and orientation of a 7 Fr ablation catheter tip. AF was induced in nine goats by intravenous infusion of methacholine (3-4 microg x kg(-1) min(-1)) and burst pacing. The three-dimensional atrial geometry was reconstructed using the median location of the mapping catheter tip during 30 seconds when in contact with each endocardial site. Sequential RF energy (60 seconds in a temperature-controlled mode [60 degrees C]) was delivered along a predetermined path to create longitudinal lesions in both atria. Sites to which RF energy was applied were tagged on the NFM map, enabling the operator to accurately navigate the catheter tip to the adjacent sites. In all cases (n = 14) the location, shape, length, and continuity of the linear lesions on the electroanatomic maps highly correlated with the autopsy findings. Average line length on the reconstructed maps was 32.3+/-4.1 mm, which highly correlated (r = 0.98, P<.001) with the lesions created in the pathological specimen (31.7+/-3.9 mm). The NFM system can guide the application of RF linear lesions in a highly accurate manner during AF. Moreover, the ability to tag the ablation sites on the three-dimensional maps together with real-time monitoring of the ablation catheter tip location enables delivery of RF energy to create reproducible, continuous, longitudinal lesions without the use of fluoroscopy.

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal

Effect directionunclear

PopulationGoats with induced atrial fibrillation

Sample size9

ExposureRF · 60 seconds per RF application (temperature-controlled mode at 60°C)

Evidence strengthLowConfidence: 74% · Peer reviewed: yes

Main findings

Outcomes measured

Accuracy of guiding continuous linear RF lesions using nonfluoroscopic electroanatomic mapping (Carto)
Correlation of lesion location/shape/length/continuity on maps vs autopsy findings
Lesion line length (map vs pathological specimen)
Ability to create reproducible continuous longitudinal lesions without fluoroscopy

Limitations

Frequency of RF energy not reported
No explicit health outcome assessment beyond procedural/lesion accuracy
Animal model (goats) with induced AF; generalizability to humans not addressed in abstract
Sample size limited (9 goats; 14 lesion sets/cases)

View raw extracted JSON

{
  "study_type": "animal",
  "exposure": {
    "band": "RF",
    "source": "medical ablation catheter (radiofrequency energy)",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": "60 seconds per RF application (temperature-controlled mode at 60°C)"
  },
  "population": "Goats with induced atrial fibrillation",
  "sample_size": 9,
  "outcomes": [
    "Accuracy of guiding continuous linear RF lesions using nonfluoroscopic electroanatomic mapping (Carto)",
    "Correlation of lesion location/shape/length/continuity on maps vs autopsy findings",
    "Lesion line length (map vs pathological specimen)",
    "Ability to create reproducible continuous longitudinal lesions without fluoroscopy"
  ],
  "main_findings": "In 14 cases, the location, shape, length, and continuity of linear lesions on electroanatomic maps highly correlated with autopsy findings. Average line length on reconstructed maps (32.3±4.1 mm) highly correlated with pathological specimen measurements (31.7±3.9 mm; r=0.98, P<.001).",
  "effect_direction": "unclear",
  "limitations": [
    "Frequency of RF energy not reported",
    "No explicit health outcome assessment beyond procedural/lesion accuracy",
    "Animal model (goats) with induced AF; generalizability to humans not addressed in abstract",
    "Sample size limited (9 goats; 14 lesion sets/cases)"
  ],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "atrial fibrillation",
    "radiofrequency ablation",
    "electroanatomic mapping",
    "nonfluoroscopic mapping",
    "Carto",
    "magnetic fields",
    "goat model",
    "linear lesions"
  ],
  "suggested_hubs": [
    {
      "slug": "engineering",
      "weight": 0.55,
      "reason": "Evaluates accuracy of a nonfluoroscopic electroanatomic mapping system using magnetic fields to guide RF lesion creation."
    }
  ]
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1046/j.1460-9592.2001.01672.x
PubMed: 11816638

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