In vivo modulation of ETS genes induced by electromagnetic fields.

In vivo (Athens, Greece) · 2001 · Mixed · Low evidence

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MixedLow evidencePaper 3891

BALB/c mice exposed to 50 MHz radiation (80% modulated at 16 Hz) showed increased ETS1 mRNA and protein expression in spleen, while ETS2 protein levels decreased, compared with controls.

Study snapshot

PublicationIn vivo (Athens, Greece) · 2001

Study typeanimal

Reported directionMixed

Evidence ratingLow

Abstract

We have previously shown that electromagnetic field (EMF) exposure induces ETS1 oncogene overexpression in different cell lines. In order to investigate in vivo EMF effects, BALB/c mice were exposed at different times to 50 MHz radiation, modulated (80%) at 16 Hz. The exposed and control animals were sacrificed and the spleen excised for rt-pcr and western blot analysis. We observed an increase in ETS1 mRNA and protein expression, but a decrease in ETS2 protein levels. Preliminary results from this experimental model show in vivo evidence of the effect of EMF on ETS oncogene expression.

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal

Effect directionmixed

PopulationBALB/c mice

Sample sizeNot supplied

ExposureRF · 50 MHz · different times

Evidence strengthLowConfidence: 74% · Peer reviewed: yes

Main findings

BALB/c mice exposed to 50 MHz radiation (80% modulated at 16 Hz) showed increased ETS1 mRNA and protein expression in spleen, while ETS2 protein levels decreased, compared with controls.

Outcomes measured

ETS1 mRNA expression (spleen)
ETS1 protein expression (spleen)
ETS2 protein levels (spleen)

Limitations

Exposure duration/timing not specified beyond 'different times'
Sample size not reported in abstract
Only spleen tissue assessed
Results described as preliminary

View raw extracted JSON

{
  "study_type": "animal",
  "exposure": {
    "band": "RF",
    "source": null,
    "frequency_mhz": 50,
    "sar_wkg": null,
    "duration": "different times"
  },
  "population": "BALB/c mice",
  "sample_size": null,
  "outcomes": [
    "ETS1 mRNA expression (spleen)",
    "ETS1 protein expression (spleen)",
    "ETS2 protein levels (spleen)"
  ],
  "main_findings": "BALB/c mice exposed to 50 MHz radiation (80% modulated at 16 Hz) showed increased ETS1 mRNA and protein expression in spleen, while ETS2 protein levels decreased, compared with controls.",
  "effect_direction": "mixed",
  "limitations": [
    "Exposure duration/timing not specified beyond 'different times'",
    "Sample size not reported in abstract",
    "Only spleen tissue assessed",
    "Results described as preliminary"
  ],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "electromagnetic fields",
    "RF exposure",
    "50 MHz",
    "16 Hz modulation",
    "BALB/c mice",
    "spleen",
    "RT-PCR",
    "western blot",
    "ETS1",
    "ETS2",
    "oncogene expression"
  ],
  "suggested_hubs": []
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: Not supplied
PubMed: 11887334

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