Function of Ca-pump in sarcoplasmic reticulum of rat myocardium during adaptation to electromagnetic field.
← Research streamAdaptation to an electromagnetic field did not change the rate of endogenous respiration (including ouabain-sensitive respiration) in rat myocardium, but potentiated coupling between catalytic activity and Ca-transporting capacity of the sarcoplasmic reticulu…
Study snapshot
Abstract
We studied the effect of adaptation to electromagnetic field on functional state of Ca-pump in sarcoplasmic reticulum, intensity of lipid peroxidation, and energy metabolism in rat myocardium. Membrane viscosity was assessed in crude preparation of myocardial sarcoplasmic reticulum. Adaptation to electromagnetic field did not change the rate of endogenous respiration, including ouabain-sensitive respiration, but potentiated coupling between catalytic activity and Ca-transporting capacity of Ca-pump. It is hypothesized that modification of structural and functional properties of the membrane due to inhibition of free radical processes increases functional activity of Ca-pump in sarcoplasmic reticulum.
AI evidence extraction
Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.
Main findings
Adaptation to an electromagnetic field did not change the rate of endogenous respiration (including ouabain-sensitive respiration) in rat myocardium, but potentiated coupling between catalytic activity and Ca-transporting capacity of the sarcoplasmic reticulum Ca-pump.
Outcomes measured
- Ca-pump functional state in sarcoplasmic reticulum
- Lipid peroxidation intensity
- Energy metabolism/endogenous respiration (including ouabain-sensitive respiration)
- Membrane viscosity
Limitations
- No exposure parameters reported (e.g., frequency, intensity, duration).
- Sample size not reported in the abstract.
- Details of study design and controls are not provided in the abstract.
View raw extracted JSON
{
"study_type": "animal",
"exposure": {
"band": null,
"source": "electromagnetic field",
"frequency_mhz": null,
"sar_wkg": null,
"duration": null
},
"population": "Rats (myocardium/sarcoplasmic reticulum)",
"sample_size": null,
"outcomes": [
"Ca-pump functional state in sarcoplasmic reticulum",
"Lipid peroxidation intensity",
"Energy metabolism/endogenous respiration (including ouabain-sensitive respiration)",
"Membrane viscosity"
],
"main_findings": "Adaptation to an electromagnetic field did not change the rate of endogenous respiration (including ouabain-sensitive respiration) in rat myocardium, but potentiated coupling between catalytic activity and Ca-transporting capacity of the sarcoplasmic reticulum Ca-pump.",
"effect_direction": "mixed",
"limitations": [
"No exposure parameters reported (e.g., frequency, intensity, duration).",
"Sample size not reported in the abstract.",
"Details of study design and controls are not provided in the abstract."
],
"evidence_strength": "low",
"confidence": 0.72,
"peer_reviewed_likely": "yes",
"keywords": [
"electromagnetic field",
"adaptation",
"rat",
"myocardium",
"sarcoplasmic reticulum",
"Ca-pump",
"calcium transport",
"lipid peroxidation",
"free radicals",
"membrane viscosity",
"endogenous respiration",
"ouabain-sensitive respiration"
],
"suggested_hubs": [
{
"slug": "animal-studies",
"weight": 0.78,
"reason": "Experimental outcomes measured in rat myocardium following electromagnetic field adaptation."
}
]
}AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.
Identifiers and source
DOI: 10.1023/a:1022996625266
PubMed: 12660831
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