Effects of low level pulsed radio frequency fields on induced osteoporosis in rat bone.

{
  "study_type": "animal",
  "exposure": {
    "band": "RF",
    "source": "other",
    "frequency_mhz": 14,
    "sar_wkg": null,
    "duration": null
  },
  "population": "Rats with sciatic neurectomy-induced osteoporosis (femur and tibia)",
  "sample_size": null,
  "outcomes": [
    "Bone mineral density",
    "Bone resorption",
    "Osteoporosis progression"
  ],
  "main_findings": "In rats with sciatic neurectomy-induced osteoporosis, exposure to modulated pulsed electromagnetic fields (carrier 14 MHz, modulated at 16 Hz; 10 V peak-to-peak) was associated with a statistically significant increase in bone mineral density and a deceleration of bone resorption, suggesting reduced further osteoporosis in femur and tibia.",
  "effect_direction": "benefit",
  "limitations": [
    "Sample size not reported in abstract",
    "Exposure duration and regimen not reported in abstract",
    "Animal model (rat) limits direct generalization to humans",
    "Dosimetry (e.g., SAR) not reported in abstract"
  ],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "pulsed electromagnetic fields",
    "PEMF",
    "radiofrequency",
    "14 MHz",
    "16 Hz modulation",
    "osteoporosis",
    "bone mineral density",
    "bone resorption",
    "sciatic neurectomy",
    "rat"
  ],
  "suggested_hubs": []
}