A hybrid numerical method to compute erythrocyte TMP in low-frequency electric fields.

IEEE transactions on nanobioscience · 2003 · Unclear · Insufficient evidence

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UnclearInsufficient evidencePaper 3695

The paper describes a hybrid finite element/boundary element numerical method to compute erythrocyte transmembrane potential (TMP) induced by external low-frequency electric fields. For a spherical cell model, the method was reported as accurate, and the comp…

Study snapshot

PublicationIEEE transactions on nanobioscience · 2003

Study typeother

Reported directionUnclear

Evidence ratingInsufficient

Abstract

This paper presents a coupling method of the finite element method and the boundary element method to compute the transmembrane potential (TMP) of an erythrocyte in a low-frequency electric field. We compute an in vitro erythrocyte's TMP induced by external electric fields by this hybrid method. It takes advantage of the homogeneous characteristics from both intracellular region and extracellular region. Moreover, we may use a fine three-dimensional (3-D) mesh around the thin membrane and avoid 3-D meshes in other regions. Numerical results of a spherical cell show that the hybrid method is accurate. The computed threshold of the applied electric field for membrane electric breakdown agrees well with those experimental results. Numerical results can also guide us to locate the maximum induced TMP on the erythrocyte membrane in various electric fields. Some further applications of the hybrid method are also discussed.

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeother

Effect directionunclear

PopulationNot supplied

Sample sizeNot supplied

ExposureELF

Evidence strengthInsufficientConfidence: 74% · Peer reviewed: yes

Main findings

Outcomes measured

erythrocyte transmembrane potential (TMP)
membrane electric breakdown threshold
location of maximum induced TMP on membrane

Limitations

Primarily a numerical/methods paper; biological/health outcomes are not assessed in the abstract.
Exposure parameters (e.g., specific frequencies, field strengths) are not specified in the abstract.
Details of experimental comparisons (design, conditions) are not provided in the abstract.

View raw extracted JSON

{
  "study_type": "other",
  "exposure": {
    "band": "ELF",
    "source": null,
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": null
  },
  "population": null,
  "sample_size": null,
  "outcomes": [
    "erythrocyte transmembrane potential (TMP)",
    "membrane electric breakdown threshold",
    "location of maximum induced TMP on membrane"
  ],
  "main_findings": "The paper describes a hybrid finite element/boundary element numerical method to compute erythrocyte transmembrane potential (TMP) induced by external low-frequency electric fields. For a spherical cell model, the method was reported as accurate, and the computed applied-field threshold for membrane electric breakdown agreed well with experimental results.",
  "effect_direction": "unclear",
  "limitations": [
    "Primarily a numerical/methods paper; biological/health outcomes are not assessed in the abstract.",
    "Exposure parameters (e.g., specific frequencies, field strengths) are not specified in the abstract.",
    "Details of experimental comparisons (design, conditions) are not provided in the abstract."
  ],
  "evidence_strength": "insufficient",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "finite element method",
    "boundary element method",
    "hybrid numerical method",
    "erythrocyte",
    "transmembrane potential",
    "low-frequency electric field",
    "membrane breakdown"
  ],
  "suggested_hubs": [
    {
      "slug": "engineering-modeling",
      "weight": 0.9,
      "reason": "Develops and validates a numerical method (FEM/BEM coupling) to compute cell TMP in low-frequency electric fields."
    }
  ]
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1109/tnb.2003.813933
PubMed: 15382666

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