[The activity of prooxidant-antioxidant system in loach embryos under the action of microwave radiation].

Ukrainian biochemical journal · 2014 · Mixed · Low evidence

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MixedLow evidencePaper 3032

Study snapshot

PublicationUkrainian biochemical journal · 2014

Study typeanimal

Reported directionMixed

Evidence ratingLow

Abstract

Electromagnetic radiation (EMR) affects biological organisms, primarily on the cellular level. However, the effects of EMR at low-intensity exposure on animals and state of metabolic systems are not fully defined yet. Thus, research of microwave radiation influence on the processes of lipid peroxidation and antioxidant protection system is important for understanding the mechanisms of EMR action on the cell, in particular, and organism development on the whole. The content of lipid peroxidation products--lipid hydroperoxides, thiobarbituric acid reactive substances and the activity of antioxidant enzymes--superoxide dismutase, glutathione peroxidase and catalase in loach embryos under the action of microwave radiation (GSM-900 MHz, SAR = 1.1 Vt/kg) lasting 1; 5; 10 and 20 min during early embryogenesis were studied. It has been found that content of lipid peroxidation products in germ cells undergoes significant changes under the action of low-intensity EMR. The effect of microwave radiation (1, 5, 10 min) leads to the increase of superoxide dismutase activity, nevertheless, 20 min exposure decreased this index to the level of control values as it is shown. It has been established that EMR at frequencies used for mobile communications reduce the activity of antioxidant protection system components, especially catalase and glutathione peroxidase. The growth of catalase activity at the 10-cell stage of blastomere division (P < 0.05) is an exception. The results of two-way analysis of variance attest that microwave radiation factor causes the large part of all observable modifications.

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal

Effect directionmixed

PopulationLoach embryos (early embryogenesis)

Sample sizeNot supplied

ExposureRF · 900 MHz · 1.1 W/kg · 1, 5, 10, and 20 min

Evidence strengthLowConfidence: 74% · Peer reviewed: yes

Main findings

Low-intensity GSM-900 MHz exposure (SAR 1.1 W/kg) was associated with significant changes in lipid peroxidation products in germ cells of loach embryos. Superoxide dismutase activity increased after 1, 5, and 10 min exposures, while 20 min exposure decreased it back to control levels. The study reports reduced activity of antioxidant protection components (especially catalase and glutathione peroxidase), with an exception of increased catalase activity at the 10-cell stage (P<0.05).

Outcomes measured

Lipid peroxidation products (lipid hydroperoxides, thiobarbituric acid reactive substances)
Antioxidant enzyme activity (superoxide dismutase, glutathione peroxidase, catalase)

Limitations

Sample size not reported in the abstract
Animal embryo model; generalizability to humans not addressed
Exposure conditions beyond frequency, SAR, and duration (e.g., modulation details, power density, temperature control) not described in the abstract

View raw extracted JSON

{
  "study_type": "animal",
  "exposure": {
    "band": "RF",
    "source": "mobile phone",
    "frequency_mhz": 900,
    "sar_wkg": 1.1,
    "duration": "1, 5, 10, and 20 min"
  },
  "population": "Loach embryos (early embryogenesis)",
  "sample_size": null,
  "outcomes": [
    "Lipid peroxidation products (lipid hydroperoxides, thiobarbituric acid reactive substances)",
    "Antioxidant enzyme activity (superoxide dismutase, glutathione peroxidase, catalase)"
  ],
  "main_findings": "Low-intensity GSM-900 MHz exposure (SAR 1.1 W/kg) was associated with significant changes in lipid peroxidation products in germ cells of loach embryos. Superoxide dismutase activity increased after 1, 5, and 10 min exposures, while 20 min exposure decreased it back to control levels. The study reports reduced activity of antioxidant protection components (especially catalase and glutathione peroxidase), with an exception of increased catalase activity at the 10-cell stage (P<0.05).",
  "effect_direction": "mixed",
  "limitations": [
    "Sample size not reported in the abstract",
    "Animal embryo model; generalizability to humans not addressed",
    "Exposure conditions beyond frequency, SAR, and duration (e.g., modulation details, power density, temperature control) not described in the abstract"
  ],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "microwave radiation",
    "RF-EMR",
    "GSM-900",
    "SAR",
    "loach embryos",
    "early embryogenesis",
    "lipid peroxidation",
    "oxidative stress",
    "superoxide dismutase",
    "catalase",
    "glutathione peroxidase"
  ],
  "suggested_hubs": [
    {
      "slug": "mobile-phones-rf",
      "weight": 0.9,
      "reason": "Exposure described as GSM-900 MHz at SAR 1.1 W/kg, frequencies used for mobile communications."
    }
  ]
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: Not supplied
PubMed: 25816598

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