Using ultrasound radio frequency technology to assess regression of the structure and function of the carotid artery by radioiodine therapy in hyperthyroidism patients.

Archives of medical science : AMS · 2015 · Benefit · Low evidence

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BenefitLow evidencePaper 2996

At baseline, hyperthyroid patients had higher IMT, higher β and PWV, and lower CC than healthy controls. After 131I treatment, IMT decreased and β and PWV decreased while CC increased versus baseline; several parameters correlated with age and systolic blood …

Study snapshot

PublicationArchives of medical science : AMS · 2015

Study typecohort

Reported directionBenefit

Evidence ratingLow

Abstract

INTRODUCTION: The aim of the study was to investigate the structure and function of the carotid artery in patients with hyperthyroidism by ultrasound radio frequency data technology (RF data) and the effect of (131)I on them. MATERIAL AND METHODS: Seventy patients with primary hyperthyroidism and 74 healthy volunteers were enrolled in this study. Structural and functional parameters of the common carotid artery were measured in every patient before and after (131)I treatment through the RF data, such as intima media thickness (IMT), functional compliance coefficient (CC), stiffness index (β), and pulse wave velocity (PWV). We also analyzed the correlation between these parameters and patients' age, body mass index, hemodynamic parameters (blood pressure, heart rate), thyroid hormone levels and other risk factors. RESULTS: There was a significant difference in IMT between hyperthyroid patients and the control group at baseline (483.6 vs. 443.3 µm, p < 0.01); after treatment, the IMT decreased significantly (428.7 vs. 483.6 µm, p < 0.001). Furthermore, the IMT was correlated with patients' age and systolic blood pressure (r = 0.525, p < 0.01 and r = 0.289, p < 0.05, respectively). The β and PWV were also higher than the control group (7.26 vs.5.87, 6.27 vs. 5.57 m/s, respectively; all p < 0.001); CC was lower than the control group (0.98 vs. 1.19 mm(2)/KPa, p < 0.01); after treatment, PWV and β were lower than baseline (5.66 vs. 6.27, 5.81 vs. 7.26 m/s, respectively; all p < 0.01), and CC was higher than baseline. In addition, they were significantly correlated with age (r = 0.525, p < 0.01 and r = 0.289, p < 0.05, respectively). However, these parameters were not correlated with the level of thyroid hormones. CONCLUSIONS: Six-month (131)I treatment for patients with hyperthyroidism reverses the structural and functional damage in the carotid artery, which is sensitively evaluated by the RF data technique.

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AI evidence extraction

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Study typecohort

Effect directionbenefit

PopulationPatients with primary hyperthyroidism and healthy volunteers (controls)

Sample size144

Exposure6 months (131I treatment)

Evidence strengthLowConfidence: 74% · Peer reviewed: yes

Main findings

Outcomes measured

Common carotid artery intima-media thickness (IMT)
Compliance coefficient (CC)
Stiffness index (β)
Pulse wave velocity (PWV)
Correlations with age, BMI, hemodynamic parameters (blood pressure, heart rate), thyroid hormone levels, other risk factors

View raw extracted JSON

{
  "study_type": "cohort",
  "exposure": {
    "band": null,
    "source": "medical imaging (ultrasound RF data technology) / radioiodine therapy (131I)",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": "6 months (131I treatment)"
  },
  "population": "Patients with primary hyperthyroidism and healthy volunteers (controls)",
  "sample_size": 144,
  "outcomes": [
    "Common carotid artery intima-media thickness (IMT)",
    "Compliance coefficient (CC)",
    "Stiffness index (β)",
    "Pulse wave velocity (PWV)",
    "Correlations with age, BMI, hemodynamic parameters (blood pressure, heart rate), thyroid hormone levels, other risk factors"
  ],
  "main_findings": "At baseline, hyperthyroid patients had higher IMT, higher β and PWV, and lower CC than healthy controls. After 131I treatment, IMT decreased and β and PWV decreased while CC increased versus baseline; several parameters correlated with age and systolic blood pressure, but were not correlated with thyroid hormone levels.",
  "effect_direction": "benefit",
  "limitations": [],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "hyperthyroidism",
    "radioiodine",
    "131I",
    "carotid artery",
    "intima-media thickness",
    "pulse wave velocity",
    "stiffness index",
    "compliance coefficient",
    "ultrasound radio frequency data"
  ],
  "suggested_hubs": []
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.5114/aoms.2015.53294
PubMed: 26788085

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